Evaluation of novel urinary tract infection biomarkers in children

Pediatricians frequently use urinalysis to diagnose urinary tract infection (UTI) while awaiting urine culture results, but sensitivity and specificity of urinalysis are limited. This study evaluated the diagnostic accuracy of the antimicrobial peptides (AMPs) human α-defensin 5 (HD5) and human neutrophil peptides (HNP) 1–3 as novel UTI biomarkers in children. We prospectively enrolled 199 pediatric Emergency Department or Urgent Care patients...