Novel pH-Sensitive Chitosan Nanoparticles for Oral Insulin Delivery: Mechanism, Biodistribution, Toxicological, Pharmacodynamic and Pharmacokinetic Evaluations

The present dissertation was aimed at evaluating the mechanism, safety and efficacy of novel pH-sensitive nanoparticles (NPs) for the oral delivery of insulin. The self-assembled NPs with pH-responsive characteristics were prepared by mixing the anionic poly-r-glutamic acid solution with the cationic chitosan (CS) solution in the presence of MgSO4 and sodium tripolyphosphate. The absorption enhancing potential of the test NPs was evaluated using...