Crystal structure of the Rous sarcoma virus intasome
Abstract
Integration of the reverse-transcribed viral DNA into the host genome is an essential step in the life cycle of retroviruses. Retrovirus integrase catalyses insertions of both ends of the linear viral DNA into a host chromosome. Integrase from HIV-1 and closely related retroviruses share the three-domain organization, consisting of a catalytic core domain flanked by amino- and carboxy-terminal domains essential for the concerted integration...
Paper Details
Title
Crystal structure of the Rous sarcoma virus intasome
Published Date
Feb 1, 2016
Journal
Volume
530
Issue
7590
Pages
362 - 366
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