Review paper
Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery
Abstract
Thiazolo[4,5-d]pyrimidines are fused heterocyclic ring-systems that can be viewed at the first glance as purine isosteres. They are the 7 thia-analogs of purines via the replacement of the nitrogen at position 7 of the purine ring by a sulfur atom. Because of the structural resemblance to adenine and guanine and their related derivatives as adenosine, guanosine, cAMP, cGMP and similar biomolecules, many thiazolo[4,5-d]pyrimidines scaffold were...
Paper Details
Title
Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery
Published Date
May 1, 2016
Volume
113
Pages
198 - 213
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