Impaired adaptation of first-phase insulin secretion in postmenopausal women with glucose intolerance

This study examined whether insulin secretion, insulin sensitivity, glucose effectiveness, and hepatic extraction of insulin are altered in subjects with impaired glucose tolerance (IGT). The frequently sampled intravenous glucose tolerance test was performed in postmenopausal women (age 63 yr, body mass index range 21.6–28.9 kg/m 2 ) with IGT ( n = 10) or normal glucose tolerance (NGT; n = 10). Insulin sensitivity (S I ) was significantly lower...