Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility
Abstract
Approximately 25–30% of colorectal cancer (CRC) cases are expected to result from a genetic predisposition, but in only 5–10% of these cases highly penetrant germline mutations are found. The remaining CRC heritability is still unexplained, and may be caused by a hitherto-undefined set of rare variants with a moderately penetrant risk. Here we aimed to identify novel risk factors for early-onset CRC using whole-exome sequencing, which was...
Paper Details
Title
Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility
Published Date
Feb 22, 2016
Journal
Volume
12
Issue
2
Pages
e1005880 - e1005880
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