Whole-genome mutational burden analysis of three pluripotency induction methods

Volume: 7, Issue: 1, Pages: 10536 - 10536
Published: Feb 19, 2016
Abstract
There is concern that the stresses of inducing pluripotency may lead to deleterious DNA mutations in induced pluripotent stem cell (iPSC) lines, which would compromise their use for cell therapies. Here we report comparative genomic analysis of nine isogenic iPSC lines generated using three reprogramming methods: integrating retroviral vectors, non-integrating Sendai virus and synthetic mRNAs. We used whole-genome sequencing and de novo genome...
Paper Details
Title
Whole-genome mutational burden analysis of three pluripotency induction methods
Published Date
Feb 19, 2016
Volume
7
Issue
1
Pages
10536 - 10536
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