Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review
Abstract
Background Personalized medicine is a growing area of research which aims to tailor the treatment given to a patient according to one or more personal characteristics. These characteristics can be demographic such as age or gender, or biological such as a genetic or other biomarker. Prior to utilizing a patient’s biomarker information in clinical practice, robust testing in terms of analytical validity, clinical validity and clinical utility is...
Paper Details
Title
Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review
Published Date
Feb 24, 2016
Journal
Volume
11
Issue
2
Pages
e0149803 - e0149803
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Notes
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