Pioglitazone after Ischemic Stroke or Transient Ischemic Attack

Patients with ischemic stroke or transient ischemic attack (TIA) are at increased risk for future cardiovascular events despite current preventive therapies. The identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients with cerebrovascular disease.In this multicenter, double-blind trial, we randomly assigned 3876...