Depression Risk Predicts Blunted Neural Responses to Gains and Enhanced Responses to Losses in Healthy Children

Maternal major depressive disorder (MDD) increases risk for MDD and predicts reduced reward responding in adolescent offspring. However, it is unclear whether alterations in neural response to reward can be detected in school-aged children at high risk before the typical increase in reward response observed in adolescence.To assess relationships between neural response to gain/loss feedback, MDD risk, and child depressive symptoms, 47...