A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
Abstract
Activation of brown and beige fat can reduce obesity and improve glucose homeostasis through nonshivering thermogenesis. Whether brown or beige fat also secretes paracrine or endocrine factors to promote and amplify adaptive thermogenesis is not fully explored. Here we identify Slit2, a 180 kDa member of the Slit extracellular protein family, as a PRDM16-regulated secreted factor from beige fat cells. In isolated cells and in mice, full-length...
Paper Details
Title
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
Published Date
Mar 1, 2016
Journal
Volume
23
Issue
3
Pages
454 - 466
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