Circulating Extracellular Histones Are Clinically Relevant Mediators of Multiple Organ Injury.

Volume: 186, Issue: 4, Pages: 829 - 843
Published: Apr 1, 2016
Abstract
Extracellular histones are a damage-associated molecular pattern (DAMP) involved in the pathogenesis of various diseases. The mechanisms of histone-mediated injury in certain organs have been extensively studied, but an understanding of the pathophysiological role of histone-mediated injury in multiple organ injury remains elusive. To elucidate this role, we systemically subjected C57BL/6 mice to various doses of histones and performed a...
Paper Details
Title
Circulating Extracellular Histones Are Clinically Relevant Mediators of Multiple Organ Injury.
Published Date
Apr 1, 2016
Volume
186
Issue
4
Pages
829 - 843
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