Different biological effects of a constant dose for single UVB irradiation with different intensities and exposure times

Ultraviolet (UV) irradiation induces not only local damage targeting external organs but also systemic damage targeting internal organs. Skin erythema, erosion and ulcers are representative types of local damage induced by UV irradiation 1, 2. Minimum erythema dose (MED) is used as a worldwide standard biomarker for UV-mediated local damage considering individual skin characteristics 3. Immunosuppression of contact hypersensitivity (CHS) is a...