Mitochondria are required for pro‐ageing features of the senescent phenotype

Volume: 35, Issue: 7, Pages: 724 - 742
Published: Apr 1, 2016
Abstract
Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype, which involves an overproduction of pro-inflammatory and pro-oxidant signals. However, the exact mechanisms regulating these phenotypes remain poorly understood. Here, we show the critical role of mitochondria in cellular senescence. In multiple models of senescence, absence of mitochondria...
Paper Details
Title
Mitochondria are required for pro‐ageing features of the senescent phenotype
Published Date
Apr 1, 2016
Volume
35
Issue
7
Pages
724 - 742
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