Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect

Background Childhood maltreatment is the most important preventable cause of psychopathology accounting for about 45% of the population attributable risk for childhood onset psychiatric disorders. A key breakthrough has been the discovery that maltreatment alters trajectories of brain development. Methods This review aims to synthesize neuroimaging findings in children who experienced caregiver neglect as well as from studies in children,...