Brain-derived neurotrophic factor and its clinical implications
Abstract
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production,...
Paper Details
Title
Brain-derived neurotrophic factor and its clinical implications
Published Date
Jan 1, 2015
Journal
Volume
6
Pages
1164 - 1178
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Notes
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