Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients

Published on Apr 1, 2016in Journal of Cancer Research and Clinical Oncology3.33
· DOI :10.1007/s00432-015-2095-y
Jens Köhler8
Estimated H-index: 8
(Harvard University),
Martin Schuler48
Estimated H-index: 48
+ 21 AuthorsAlexander Baraniskin14
Estimated H-index: 14
(RUB: Ruhr University Bochum)
Purpose Lung cancer accounts for one in five cancer deaths. Broad screening strategies for high-risk populations are unavailable, and the validation of biomarkers for early cancer detection remains a prime interest. Therefore, we investigated the value of circulating U2 small nuclear RNA fragments (RNU2-1f) as a biomarker for diagnosis, prognosis estimation and treatment monitoring in a large lung cancer cohort.
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