Original paper
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Abstract
Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16(Ink4a) (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells and has beneficial roles in tissue remodelling during embryogenesis and wound healing. Senescent cells accumulate in various tissues and organs over time, and have been speculated to have a...
Paper Details
Title
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Published Date
Feb 1, 2016
Journal
Volume
530
Issue
7589
Pages
184 - 189
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Notes
History