A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Published on Feb 1, 2016in Phytochemistry2.905
· DOI :10.1016/j.phytochem.2015.12.007
Yasodha Sivasothy10
Estimated H-index: 10
(UM: University of Malaya),
Kong Yong Loo1
Estimated H-index: 1
(UM: University of Malaya)
+ 2 AuthorsKhalijah Awang29
Estimated H-index: 29
(UM: University of Malaya)
Abstract A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC 50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC 50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver–Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.
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