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Collection of Wound Exudate From Human Digit Tip Amputations Does Not Impair Regenerative Healing: A Randomized Trial.

Published on Oct 1, 2015in Medicine 2.03
· DOI :10.1097/MD.0000000000001764
Tobias Kisch4
Estimated H-index: 4
,
Julia Maria Klemens1
Estimated H-index: 1
+ 7 AuthorsMatthias Brandenburger3
Estimated H-index: 3
Abstract
AbstractThe regrowth of amputated digit tips represents a unique regenerative healing in mammals with subcutaneous volume regrowth, restoration of dactylogram, and suppression of scar formation. Although factor analysis in amphibians and even in mice is easy to obtain, safety of harvesting biomateri
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  • Citations (2)
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References39
Newest
Published on Mar 1, 2015in Hand
C. Liam Dwyer2
Estimated H-index: 2
(UPMC Hamot),
D. Dean Dominy1
Estimated H-index: 1
(Houston Methodist Hospital)
+ 3 AuthorsJohn D. Lubahn14
Estimated H-index: 14
(UPMC Hamot)
Purpose This study was conducted to compare the in vitro biomechanical properties of tensile strength and gap resistance of a double grasping loop (DGL) flexor tendon repair with the established four-strand cross-locked cruciate (CLC) flexor tendon repair, both with an interlocking horizontal mattress (IHM) epitendinous suture. The hypothesis is that the DGL-IHM method which utilizes two looped core sutures, grasping and locking loops, and a single intralesional knot will have greater strength a...
7 Citations Source Cite
Published on Dec 1, 2014in Tissue Engineering Part A
Kristen M. Lynch4
Estimated H-index: 4
,
Tabassum Ahsan13
Estimated H-index: 13
The capacity to regenerate complex tissue structures after amputation in humans is limited to the digit tip. In a comparable mouse digit model, which includes both distal regeneration-competent and proximal regeneration-incompetent regions, successful regeneration involves precise orchestration of complex microenvironmental cues, including paracrine signaling via heterogeneous cell–cell interactions. Initial cellular processes, such as proliferation and migration, are critical in the formation o...
8 Citations Source Cite
Yuval Rinkevich12
Estimated H-index: 12
,
Daniel T. Montoro20
Estimated H-index: 20
+ 7 AuthorsMichael T. Longaker97
Estimated H-index: 97
The requirement and influence of the peripheral nervous system on tissue replacement in mammalian appendages remain largely undefined. To explore this question, we have performed genetic lineage tracing and clonal analysis of individual cells of mouse hind limb tissues devoid of nerve supply during regeneration of the digit tip, normal maintenance, and cutaneous wound healing. We show that cellular turnover, replacement, and cellular differentiation from presumed tissue stem/progenitor cells wit...
33 Citations Source Cite
Published on Apr 1, 2014in Developmental Cell 9.62
Valerie A. Tornini5
Estimated H-index: 5
(Howard Hughes Medical Institute),
Kenneth D. Poss50
Estimated H-index: 50
(Howard Hughes Medical Institute)
Regeneration of a lost appendage in adult amphibians and fish is a remarkable feat of developmental patterning. Although the limb or fin may be years removed from its initial creation by an embryonic primordium, the blastema that emerges at the injury site fashions a close mimic of adult form. Central to understanding these events are revealing the cellular origins of new structures, how positional identity is maintained, and the determinants for completion. Each of these topics has been advance...
32 Citations Source Cite
Published on Oct 1, 2013in Developmental Biology 3.26
Jangwoo Lee8
Estimated H-index: 8
(Tulane University),
Luis Marrero23
Estimated H-index: 23
(Louisiana State University)
+ 3 AuthorsManjong Han13
Estimated H-index: 13
(Tulane University)
Abstract Previously we demonstrated that BMP signaling is required for endogenous digit tip regeneration, and that treatment with BMP-2 or -7 induces a regenerative response following amputation at regeneration-incompetent levels ( Yu et al., 2010 , Yu et al., 2012 ). Both endogenous regeneration and BMP-induced regeneration are associated with the transient formation of a blastema, however the formation of a regeneration blastema in mammals is poorly understood. In this study, we focus on how b...
24 Citations Source Cite
Published on Jul 1, 2013in Nature 41.58
Makoto Takeo6
Estimated H-index: 6
(New York University),
Wei Chin Chou2
Estimated H-index: 2
(New York University)
+ 5 AuthorsMayumi Ito19
Estimated H-index: 19
(New York University)
Nail stem cells (NSCs) reside in the proximal nail matrix, and early nail progenitors undergo Wnt-dependent differentiation into the nail; after amputation, Wnt activation is required for nail and digit regeneration, and amputations proximal to the Wnt-active nail progenitors fail to regenerate, but β-catenin stabilization in the NSC region induces regeneration.
116 Citations Source Cite
Published on Jun 1, 2013in Tissue Engineering Part A
Kristen M. Lynch4
Estimated H-index: 4
,
Tabassum Ahsan13
Estimated H-index: 13
Epimorphic regeneration in humans of complex multitissue structures is primarily limited to the digit tip. In a comparable mouse model, the response is level-specific in that regeneration occurs after amputation at the distal end of the terminal phalanx, but not more proximally. Recent isolation of stromal cells from CD1 murine phalangeal elements two and three (P2 and P3) allow for comparative studies of cells prevalent at the amputation plane of a more proximal region (considered nonregenerati...
7 Citations Source Cite
Published on Mar 1, 2013in Wound Repair and Regeneration 2.95
Takeo Minematsu13
Estimated H-index: 13
(University of Tokyo),
Gojiro Nakagami19
Estimated H-index: 19
(University of Tokyo)
+ 10 AuthorsNobuhiko Haga23
Estimated H-index: 23
(University of Tokyo)
Because wound exudate includes secreted proteins that affect wound healing, its biochemical analysis is useful for objective assessment of chronic wounds. Wound blotting allows for collection of fresh exudate by attaching a nitrocellulose membrane onto the wound surface. To determine its applicability for several analysis methods and its executability in clinical wound assessment, this study comprised an animal experiment and clinical case reports. In the animal experiment, full-thickness wounds...
15 Citations Source Cite
Published on Jan 18, 2013in PLOS ONE 2.77
Yuanyuan Wu1
Estimated H-index: 1
(Tulane University),
Karen Wang1
Estimated H-index: 1
(Tulane University)
+ 5 AuthorsKen Muneoka24
Estimated H-index: 24
(Tulane University)
A key factor that contributes to the regenerative ability of regeneration-competent animals such as the salamander is their use of innate positional cues that guide the regeneration process. The limbs of mammals has severe regenerative limitations, however the distal most portion of the terminal phalange is regeneration competent. This regenerative ability of the adult mouse digit is level dependent: amputation through the distal half of the terminal phalanx (P3) leads to successful regeneration...
28 Citations Source Cite
Published on Jan 1, 2013in Methods of Molecular Biology
Jennifer Simkin10
Estimated H-index: 10
(Tulane University),
Manjong Han13
Estimated H-index: 13
(Tulane University)
+ 2 AuthorsKen Muneoka24
Estimated H-index: 24
(Tulane University)
23 Citations Source Cite
Cited By2
Newest
Ranieri Cancedda63
Estimated H-index: 63
,
Sveva Bollini18
Estimated H-index: 18
+ 2 AuthorsRoberta Tasso16
Estimated H-index: 16
For repair of chronic or difficult to heal tissue lesions and defects, major constraints exist to a broad application of cell therapy and tissue engineering approaches, i.e. transplantation of “ex vivo” expanded autologous stem/progenitor cells, alone or associated to carrier biomaterials. To enable a large number of patients to benefit, new strategies should be considered. One of the main goals of contemporary Regenerative Medicine is to develop new regenerative therapies, inspired from Mother ...
7 Citations Source Cite