Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Abstract
While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long-term senolytic treatment is unknown. To determine whether long-term senolytic treatment improves vasomotor function, vascular stiffness, and intimal plaque size and composition in aged or hypercholesterolemic mice with established disease. Senolytic treatment (intermittent treatment with Dasatinib + Quercetin via oral...
Paper Details
Title
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Published Date
Aug 5, 2016
Journal
Volume
15
Issue
5
Pages
973 - 977
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