Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

Significance To our knowledge, this article is the first report explaining how cFLIP, an inhibitor of apoptosis, regulates apoptosis in vivo. Although the antiapoptotic role of cFLIP was proposed based on in vitro studies and the early embryonic lethality of cFLIP-deficient mice, the specific role of cFLIP L (long) and cFLIP R (short) isoforms is poorly understood. In this study, we describe a previously unidentified allele of caspase 8- and...