Match!

Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris

Published on Feb 24, 2016in Journal of Agricultural and Food Chemistry3.57
· DOI :10.1021/acs.jafc.5b05931
Ching Peng Chiu3
Estimated H-index: 3
(KMU: Kaohsiung Medical University),
Shan Chi Liu5
Estimated H-index: 5
(PRC: China Medical University (PRC))
+ 7 AuthorsWuYang-Chang46
Estimated H-index: 46
Cite
Abstract
Cordyceps militaris (bei-chong-chaw, northern worm grass) is a precious and edible entomopathogenic fungus, which is widely used in traditional Chinese medicine (TCM) as a general booster for the nervous system, metabolism, and immunity. Saccharides, nucleosides, mannitol, and sterols were isolated from this fungus. The biological activity of C. militaris was attributed to the saccharide and nucleoside contents. In this study, the aqueous methanolic fraction of C. militaris fruiting bodies exhibited a significant anti-inflammatory activity. Bioactivity-guided fractionation of the active fraction led to the isolation of eight compounds, including one new and two known cerebrosides (ceramide derivatives), two nucleosides, and three sterols. Cordycerebroside A (1), the new cerebroside, along with soyacerebroside I (2) and glucocerebroside (3) inhibited the accumulation of pro-inflammatory iNOS protein and reduced the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages. This is the first study ...
  • References (42)
  • Citations (17)
Cite
References42
Newest
#1Neeranjini Nallathamby (UM: University of Malaya)H-Index: 3
#2Guan-Serm L (UM: University of Malaya)H-Index: 1
Last.Sabaratnam (UM: University of Malaya)H-Index: 2
view all 6 authors...
#1Xiaofeng Yang (Xi'an Jiaotong University)H-Index: 8
#2Yanxiang Li (Xi'an Jiaotong University)H-Index: 8
Last.Rong Lin (Xi'an Jiaotong University)H-Index: 18
view all 9 authors...
#1Fhernanda R. Smiderle (UFPR: Federal University of Paraná)H-Index: 17
#2Cristiane Hatsuko Baggio (UFPR: Federal University of Paraná)H-Index: 27
Last.Leo J.L.D. Van Griensven (WUR: Wageningen University and Research Centre)H-Index: 25
view all 7 authors...
#1Jing Zhao (UM: University of Macau)H-Index: 28
#2Jing Xie (UM: University of Macau)H-Index: 9
Last.S.P. Li (UM: University of Macau)H-Index: 31
view all 4 authors...
#1Kai Yue (Sichuan Agricultural University)H-Index: 8
#2Meng Ye (Sichuan Agricultural University)H-Index: 2
Last.Xiao Lin (Sichuan Agricultural University)H-Index: 2
view all 5 authors...
#1Peng Zheng (CAS: Chinese Academy of Sciences)H-Index: 14
#2Yongliang Xia (CAS: Chinese Academy of Sciences)H-Index: 7
Last.Chengshu Wang (CAS: Chinese Academy of Sciences)H-Index: 38
view all 4 authors...
Cited By17
Newest
#1Wen-Jun Wei (Lanzhou University)H-Index: 3
#2Weiyan Qi (CPU: China Pharmaceutical University)
Last.Kun Gao (Lanzhou University)H-Index: 18
view all 8 authors...
#1Nilawan Surapong (MSU: Mahasarakham University)H-Index: 1
#2Aphidech Sangdee (MSU: Mahasarakham University)H-Index: 4
Last.Prapairat Seephonkai (MSU: Mahasarakham University)H-Index: 3
view all 6 authors...
#1Yanjun Zhang (GXNU: Guangxi Normal University)H-Index: 2
#2Xishan HuangH-Index: 1
Last.Jun Li (GXNU: Guangxi Normal University)H-Index: 3
view all 10 authors...
#1Ting Hu (CAU: China Agricultural University)H-Index: 4
#2Yue Liang (Shenyang Agricultural University)H-Index: 1
Last.Yanbin Guo (CAU: China Agricultural University)H-Index: 4
view all 6 authors...
#1Shan-Chi Liu (PRC: China Medical University (PRC))H-Index: 7
#2Chun-Hao Tsai (PRC: China Medical University (PRC))H-Index: 20
Last.Jai Sing Yang (PRC: China Medical University (PRC))H-Index: 45
view all 10 authors...
#1Hsiang-Ping Lee (PRC: China Medical University (PRC))H-Index: 5
#2Shih-Wei Wang (Mackay Medical College)H-Index: 22
Last.Mei-chin Yin (PRC: China Medical University (PRC))H-Index: 21
view all 10 authors...
View next paperAssays on nutrient and effective ingredients in different parts of Cordyceps militaris