CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells

Published on Dec 1, 2016in Journal of Translational Medicine 4.20
· DOI :10.1186/s12967-016-0787-y
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Luo Gu13
Estimated H-index: 13
(Nanjing Medical University)
+ 6 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Abstract
Background CD24, a mucin-like membrane glycoprotein, plays a critical role in carcinogenesis, but its role in human gastric cancer and the underlying mechanism remains undefined.
  • References (59)
  • Citations (15)
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References59
Published on Jan 1, 2007in Drugs 4.69
Michael F. Press71
Estimated H-index: 71
(University of Southern California),
H. J. Lenz75
Estimated H-index: 75
(University of Southern California)
Targeted therapies are rationally designed to interfere with specific molecular events that are important in tumour growth, progression or survival. Several targeted therapies with anti-tumour activity in human cancer cell lines and xenograft models have now been shown to produce objective responses, delay disease progression and, in some cases, improve survival of patients with advanced malignancies. These targeted therapies include cetuximab, an anti-epidermal growth factor receptor (EGFR) mon...
93 Citations Source Cite
Published on Jun 1, 2013in Hepato-gastroenterology
Takahashi M1
Estimated H-index: 1
,
Masanobu Nakajima12
Estimated H-index: 12
+ 8 AuthorsMiyachi K1
Estimated H-index: 1
13 Citations Source Cite
Published on Sep 1, 2013in Stem Cells 5.59
Adam D. Gracz12
Estimated H-index: 12
(University of North Carolina at Chapel Hill),
Megan K. Fuller6
Estimated H-index: 6
(University of North Carolina at Chapel Hill)
+ 5 AuthorsScott T. Magness29
Estimated H-index: 29
(University of North Carolina at Chapel Hill)
Recent seminal studies have rapidly advanced the understanding of intestinal epithelial stem cell (IESC) biology in murine models. However, the lack of techniques suitable for isolation and subsequent downstream analysis of IESCs from human tissue has hindered the application of these findings toward the development of novel diagnostics and therapies with direct clinical relevance. This study demonstrates that the cluster of differentiation genes CD24 and CD44 are differentially expressed across...
49 Citations Source Cite
Published on Aug 31, 2005in Genes to Cells 2.05
Takako Kaneko5
Estimated H-index: 5
(Nagoya University),
Akio Maeda8
Estimated H-index: 8
(Nagoya University)
+ 7 AuthorsKozo Kaibuchi115
Estimated H-index: 115
(Nagoya University)
After binding of epidermal growth factor (EGF), the EGF receptor is activated, internalized by endocytosis, and subsequently degraded in the lysosomal pathway. Endocytotic trafficking of the activated EGF receptor is essential for controlling EGF signaling. Upon ligand-induced activation of EGF receptors, Cbl (ubiquitin ligase) binds to the activated receptor and leads to translocation of the CIN85 (Cbl-interacting protein of 85 kDa)/endophilin complex in the vicinity of the activated EGF recept...
48 Citations Source Cite
Published on Jun 1, 2000in Nature 41.58
Wen Jin Wu12
Estimated H-index: 12
(Cornell University),
Jon W. Erickson18
Estimated H-index: 18
(Cornell University)
+ 1 AuthorsRichard A. Cerione63
Estimated H-index: 63
The Ras-related GTP-binding protein Cdc42 is implicated in a variety of biological activities including the establishment of cell polarity in yeast, the regulation of cell morphology, motility and cell-cycle progression in mammalian cells and the induction of malignant transformation 1,2 . We identified a Cdc42 mutant (Cdc42F28L) which binds GTP in the absence of a guanine nucleotide exchange factor, but still hydrolyses GTP with a turnover number identical to that for wild-type Cdc42 (ref. 3). ...
179 Citations Source Cite
Published on Dec 1, 2008in Neoplasia 4.99
Quanwen Li5
Estimated H-index: 5
(Wayne State University),
Raymond R. Mattingly22
Estimated H-index: 22
(Wayne State University)
E-cadherin is a main component of the cell-cell adhesion junctions that play a principal role in maintaining normal breast epithelial cell morphology. Breast and other cancers that have up-regulated activity of Ras are often found to have down-regulated or mislocalized E-cadherin expression. Disruption of E-cadherin junctions and consequent gain of cell motility contribute to the process known as epithelial-to-mesenchymal transition (EMT). Enforced expression of E-cadherin or inhibition of Ras-s...
53 Citations Source Cite
Published on Apr 15, 2014in Journal of Cell Science 4.40
Karla C. Williams8
Estimated H-index: 8
(University of Guelph),
Marc G. Coppolino14
Estimated H-index: 14
(University of Guelph)
Acquisition of an invasive phenotype is prerequisite for tumor metastasis. Degradation of the extracellular matrix (ECM), and subsequent invasion by tumor cells, is mediated, in part, through subcellular structures called invadopodia. Src-dependent cytoskeletal rearrangements are required to form invadopodia, and here we identify an association between Src, epidermal growth factor receptor (EGFR), and β1 integrin that facilitates invadopodia formation. The association of Src, EGFR and β1 integri...
29 Citations Source Cite
Published on Jul 1, 2014in Nature 41.58
Matthew J. Paszek8
Estimated H-index: 8
,
Christopher C. DuFort7
Estimated H-index: 7
+ 17 AuthorsLuke Cassereau7
Estimated H-index: 7
Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins, and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins — by funnelling integrins into adhesions, integrin clustering and signalling is promoted, which leads to enhanced cell survival and proliferation.
221 Citations Source Cite
Published on Nov 1, 2014in Cancer Gene Therapy 4.04
Y Zhen1
Estimated H-index: 1
,
L Guanghui1
Estimated H-index: 1
,
Z Xiefu1
Estimated H-index: 1
The epidermal growth factor receptor (EGFR) is an oncogenic trans-membranous receptor, which is overexpressed in multiple human cancers. However, the role of EGFR in gastric cancer (GC) is still elusive. In this study, we aimed to investigate the expression and molecular mechanisms of EGFR in GC cells. Forty cases of GC and the corresponding adjacent non-cancerous tissues (ANCT) were collected, and the expression of EGFR was assessed using immunohistochemistry in biopsy samples. Furthermore, EGF...
11 Citations Source Cite
Published on Oct 1, 2009in Journal of Cell Science 4.40
Inger Helene Madshus28
Estimated H-index: 28
,
Espen Stang31
Estimated H-index: 31
The epidermal growth factor receptor (EGFR; also known as ErbB1) is one of four related receptor tyrosine kinases. These receptors (EGFR, ErbB2, ErbB3 and ErbB4) are frequently overexpressed in cancer and such overexpression is associated with poor clinical outcome. Understanding the mechanisms involved in growth-factor-receptor downregulation is medically important, as several drugs that interfere with the function and trafficking of ErbB proteins are currently being developed or are already in...
91 Citations Source Cite
  • References (59)
  • Citations (15)
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Cited By15
Published on Apr 1, 2017in Pathology & Oncology Research 1.94
Deniz Arik2
Estimated H-index: 2
(Eskişehir Osmangazi University),
Cavit Can11
Estimated H-index: 11
(Eskişehir Osmangazi University)
+ 2 AuthorsÖzgül Paşaoğlu4
Estimated H-index: 4
(Eskişehir Osmangazi University)
The role of cancer stem cells in the initiation and progression of cancer has become a well-studied area of emerging research, and stem cells with different surface markers have been identified in various types of cancer. CD24 is a membrane protein that acts as the ligand for P-selectin and has been defined as a stem cell marker of colonic cancer. The immunohistochemical expression of CD24 is associated with worse patient outcomes in small cell lung cancer, hepatocellular carcinoma, breast cance...
2 Citations Source Cite
Published on Mar 1, 2017in Neurobiology of Disease 5.23
Daniel T. Gilliam1
Estimated H-index: 1
(University of Freiburg),
Vishal Menon3
Estimated H-index: 3
(University of Freiburg)
+ 1 AuthorsJan Pruszak19
Estimated H-index: 19
(University of Freiburg)
Abstract A cell's surface molecular signature enables its reciprocal interactions with the associated microenvironments in development, tissue homeostasis and pathological processes. The CD24 surface antigen (heat-stable antigen, nectadrin; small cell lung cancer antigen cluster-4) represents a prime example of a neural surface molecule that has long been known, but whose diverse molecular functions in intercellular communication we have only begun to unravel. Here, we briefly summarize the mole...
7 Citations Source Cite
Published on Jan 14, 2017in Genes 3.19
Loris De Cecco20
Estimated H-index: 20
,
Marco Giannoccaro4
Estimated H-index: 4
+ 6 AuthorsSilvana Canevari46
Estimated H-index: 46
This paper documents the process by which we, through gene and miRNA expression profiling of the same samples of head and neck squamous cell carcinomas (HNSCC) and an integrative miRNA-mRNA expression analysis, were able to identify candidate biomarkers of progression-free survival (PFS) in patients treated with cetuximab-based approaches. Through sparse partial least square–discriminant analysis (sPLS-DA) and supervised analysis, 36 miRNAs were identified in two components that clearly separate...
4 Citations Source Cite
Published on Sep 26, 2016in Investigative Ophthalmology & Visual Science 3.39
Melinda K. Duncan31
Estimated H-index: 31
(University of Delaware),
Yichen Wang2
Estimated H-index: 2
(University of Delaware)
Published on Dec 18, 2017in International Journal of Food Properties 1.84
Zeqian Li (Beijing Technology and Business University), Huan Gu (Beijing Technology and Business University)+ 3 AuthorsJin Lin2
Estimated H-index: 2
AbstractTo improve the efficiency of traditional boiling process, a new high-pressure decocting method was developed for the production of Radix Angelica sinensis (RAS) decoction with higher contents of efficacy components (Z-ligustilide and ferulic acid) and better flavor properties. Based on preliminary tests, a three-level Box–Behnken design was employed to optimise the process parameters, including decocting temperature (120–140°C), decocting time (15–45 min) and liquid/solid ratio (35:1–45:...
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Published on Feb 1, 2018in Acta Physiologica 5.93
Yueyuan Wang3
Estimated H-index: 3
(Nanjing Medical University),
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University)
+ 6 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Aim MICAL2, a cytoskeleton dynamics regulator, is identified associated with survival and metastasis of several types of cancers recently. The present study was designed to investigate the role of MICAL2 in breast cancer cell migration as well as its underlying mechanisms. Methods The relationship between MICAL2 and EGF/EGFR signaling was analyzed by using gene overexpression and knockdown techniques. Cell migration was measured by wound healing assays. Activation of EGF/EGFR singaling pathways ...
1 Citations Source Cite
Published on Oct 1, 2017in Immunology Letters 2.44
Shirin Eyvazi2
Estimated H-index: 2
(Shahid Beheshti University of Medical Sciences and Health Services),
Bahram Kazemi24
Estimated H-index: 24
(Shahid Beheshti University of Medical Sciences and Health Services)
+ 1 AuthorsSiavoush Dastmalchi18
Estimated H-index: 18
(Tabriz University of Medical Sciences)
Abstract CD24 is a heavy glycosylated protein that is overexpressed in numerous cancer and cancer stem cells. It is involved in the development, invasion, and metastasis of the cancer cells. CD24 can be considered in targeted cancer therapy as a new target. Here, phage display technology was used for the identification of novel scFv antibodies against CD24. To do so, the CD24 protein was expressed and purified from a stable transgenic CHO cell line. The cells were developed by using a CD24 encod...
6 Citations Source Cite
Published on Dec 1, 2017in BMC Complementary and Alternative Medicine 2.11
Qin Jiang3
Estimated H-index: 3
(Central South University),
Manyi Yang3
Estimated H-index: 3
(Central South University)
+ 2 AuthorsQi Zhang3
Estimated H-index: 3
(Central South University)
Background The aim of this in vitro study was to measure the enhanced anticancer effects of Res (resveratrol) on PA (paclitaxel) in HepG2 human liver cancer cells.
7 Citations Source Cite
Published on Mar 1, 2018in Cell Death and Disease 5.64
Hongwei Xia9
Estimated H-index: 9
(Sichuan University),
Xinyu Dai2
Estimated H-index: 2
(Sichuan University)
+ 6 AuthorsFeng Bi17
Estimated H-index: 17
(Sichuan University)
The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the crosstalk between these two pathways and its implications in targeted therapy remains unclear. We found that the activated EGFR signaling could bypass RhoA to promote the expression of YAP(Yes-associated protein), the core effector of the Hippo signaling, and its downstream target Cyr61. Further studies indicated that EGFR signaling ...
7 Citations Source Cite
Published on Oct 1, 2018in Molecular Neurobiology 5.08
Thomas Theis4
Estimated H-index: 4
(Rutgers University),
Anmol Singh Johal (Rutgers University)+ 2 AuthorsMelitta Schachner91
Estimated H-index: 91
(Shantou University)
Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at the formation of the neural tube during the second embryonic week in the mouse and peaks during the first postnatal week, its functional relevance is only rudimentarily understood. To gain better insights into the ...
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