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CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells
Background CD24, a mucin-like membrane glycoprotein, plays a critical role in carcinogenesis, but its role in human gastric cancer and the underlying mechanism remains undefined.
  • References (59)
  • Cited By (15)
2007 in DrugsIF: 4.69
Michael F. Press68
Estimated H-index: 68
(University of Southern California),
Heinz-Josef Lenz72
Estimated H-index: 72
(University of Southern California)
Targeted therapies are rationally designed to interfere with specific molecular events that are important in tumour growth, progression or survival. Several targeted therapies with anti-tumour activity in human cancer cell lines and xenograft models have now been shown to produce objective responses, delay disease progression and, in some cases, improve survival of patients with advanced malignancies. These targeted therapies include cetuximab, an anti-epidermal growth factor receptor (EGFR) mon...
93 Citations Source Cite
Takahashi M1
Estimated H-index: 1
Masanobu Nakajima11
Estimated H-index: 11
+ 8 AuthorsMiyachi K1
Estimated H-index: 1
13 Citations Source Cite
2013 in Stem CellsIF: 5.59
Adam D. Gracz11
Estimated H-index: 11
(University of North Carolina at Chapel Hill),
Megan K. Fuller6
Estimated H-index: 6
(University of North Carolina at Chapel Hill)
+ 5 AuthorsScott T. Magness27
Estimated H-index: 27
(University of North Carolina at Chapel Hill)
Recent seminal studies have rapidly advanced the understanding of intestinal epithelial stem cell (IESC) biology in murine models. However, the lack of techniques suitable for isolation and subsequent downstream analysis of IESCs from human tissue has hindered the application of these findings toward the development of novel diagnostics and therapies with direct clinical relevance. This study demonstrates that the cluster of differentiation genes CD24 and CD44 are differentially expressed across...
49 Citations Source Cite
2005 in Genes to CellsIF: 2.05
Takako Kaneko5
Estimated H-index: 5
(Nagoya University),
Akio Maeda8
Estimated H-index: 8
(Nagoya University)
+ 7 AuthorsKozo Kaibuchi115
Estimated H-index: 115
(Nagoya University)
After binding of epidermal growth factor (EGF), the EGF receptor is activated, internalized by endocytosis, and subsequently degraded in the lysosomal pathway. Endocytotic trafficking of the activated EGF receptor is essential for controlling EGF signaling. Upon ligand-induced activation of EGF receptors, Cbl (ubiquitin ligase) binds to the activated receptor and leads to translocation of the CIN85 (Cbl-interacting protein of 85 kDa)/endophilin complex in the vicinity of the activated EGF recept...
48 Citations Source Cite
2000 in NatureIF: 41.58
Wen Jin Wu12
Estimated H-index: 12
(Cornell University),
Jon W. Erickson18
Estimated H-index: 18
(Cornell University)
+ 1 AuthorsRichard A. Cerione65
Estimated H-index: 65
The Ras-related GTP-binding protein Cdc42 is implicated in a variety of biological activities including the establishment of cell polarity in yeast, the regulation of cell morphology, motility and cell-cycle progression in mammalian cells and the induction of malignant transformation 1,2 . We identified a Cdc42 mutant (Cdc42F28L) which binds GTP in the absence of a guanine nucleotide exchange factor, but still hydrolyses GTP with a turnover number identical to that for wild-type Cdc42 (ref. 3). ...
176 Citations Source Cite
2008 in NeoplasiaIF: 4.99
Quanwen Li5
Estimated H-index: 5
(Wayne State University),
Raymond R. Mattingly22
Estimated H-index: 22
(Wayne State University)
E-cadherin is a main component of the cell-cell adhesion junctions that play a principal role in maintaining normal breast epithelial cell morphology. Breast and other cancers that have up-regulated activity of Ras are often found to have down-regulated or mislocalized E-cadherin expression. Disruption of E-cadherin junctions and consequent gain of cell motility contribute to the process known as epithelial-to-mesenchymal transition (EMT). Enforced expression of E-cadherin or inhibition of Ras-s...
52 Citations Source Cite
2014 in Journal of Cell ScienceIF: 4.40
Karla C. Williams8
Estimated H-index: 8
(University of Guelph),
Marc G. Coppolino15
Estimated H-index: 15
(University of Guelph)
Acquisition of an invasive phenotype is prerequisite for tumor metastasis. Degradation of the extracellular matrix (ECM), and subsequent invasion by tumor cells, is mediated, in part, through subcellular structures called invadopodia. Src-dependent cytoskeletal rearrangements are required to form invadopodia, and here we identify an association between Src, epidermal growth factor receptor (EGFR), and β1 integrin that facilitates invadopodia formation. The association of Src, EGFR and β1 integri...
27 Citations Download PDF Cite
2014 in NatureIF: 41.58
Matthew J. Paszek8
Estimated H-index: 8
Christopher C. DuFort7
Estimated H-index: 7
+ 17 AuthorsLuke Cassereau7
Estimated H-index: 7
The composition of the cellular glycocalyx a glycoprotein/polysaccharide layer that coats the cell surface changes with the changing nature of a cell through processes such as tissue differentiation and disease. Valerie Weaver and colleagues set out to establish whether changes in glycocalyx composition in cancer cells contribute to the cancer phenotype. They find that bulky glycocalyx is a feature of metastatic cancer cells, resulting from the production of large glycoproteins. The bulky glycoc...
212 Citations Source Cite
2014 in Cancer Gene TherapyIF: 4.04
Y Zhen1
Estimated H-index: 1
L Guanghui1
Estimated H-index: 1
Z Xiefu1
Estimated H-index: 1
The epidermal growth factor receptor (EGFR) is an oncogenic trans-membranous receptor, which is overexpressed in multiple human cancers. However, the role of EGFR in gastric cancer (GC) is still elusive. In this study, we aimed to investigate the expression and molecular mechanisms of EGFR in GC cells. Forty cases of GC and the corresponding adjacent non-cancerous tissues (ANCT) were collected, and the expression of EGFR was assessed using immunohistochemistry in biopsy samples. Furthermore, EGF...
11 Citations Source Cite
2009 in Journal of Cell ScienceIF: 4.40
Inger Helene Madshus28
Estimated H-index: 28
Espen Stang30
Estimated H-index: 30
The epidermal growth factor receptor (EGFR; also known as ErbB1) is one of four related receptor tyrosine kinases. These receptors (EGFR, ErbB2, ErbB3 and ErbB4) are frequently overexpressed in cancer and such overexpression is associated with poor clinical outcome. Understanding the mechanisms involved in growth-factor-receptor downregulation is medically important, as several drugs that interfere with the function and trafficking of ErbB proteins are currently being developed or are already in...
89 Citations Download PDF Cite
  • References (59)
  • Cited By (15)
Deniz Arik2
Estimated H-index: 2
(Eskişehir Osmangazi University),
Cavit Can10
Estimated H-index: 10
(Eskişehir Osmangazi University)
+ 2 AuthorsÖzgül Paşaoğlu3
Estimated H-index: 3
(Eskişehir Osmangazi University)
The role of cancer stem cells in the initiation and progression of cancer has become a well-studied area of emerging research, and stem cells with different surface markers have been identified in various types of cancer. CD24 is a membrane protein that acts as the ligand for P-selectin and has been defined as a stem cell marker of colonic cancer. The immunohistochemical expression of CD24 is associated with worse patient outcomes in small cell lung cancer, hepatocellular carcinoma, breast cance...
2 Citations Source Cite
2017 in Neurobiology of DiseaseIF: 5.23
Daniel T. Gilliam1
Estimated H-index: 1
(University of Freiburg),
Vishal Menon3
Estimated H-index: 3
(University of Freiburg)
+ 1 AuthorsJan Pruszak19
Estimated H-index: 19
(University of Freiburg)
Abstract A cell's surface molecular signature enables its reciprocal interactions with the associated microenvironments in development, tissue homeostasis and pathological processes. The CD24 surface antigen (heat-stable antigen, nectadrin; small cell lung cancer antigen cluster-4) represents a prime example of a neural surface molecule that has long been known, but whose diverse molecular functions in intercellular communication we have only begun to unravel. Here, we briefly summarize the mole...
7 Citations Source Cite
2017 in GenesIF: 3.19
Loris De Cecco21
Estimated H-index: 21
Marco Giannoccaro3
Estimated H-index: 3
+ 6 AuthorsSilvana Canevari46
Estimated H-index: 46
This paper documents the process by which we, through gene and miRNA expression profiling of the same samples of head and neck squamous cell carcinomas (HNSCC) and an integrative miRNA-mRNA expression analysis, were able to identify candidate biomarkers of progression-free survival (PFS) in patients treated with cetuximab-based approaches. Through sparse partial least square–discriminant analysis (sPLS-DA) and supervised analysis, 36 miRNAs were identified in two components that clearly separate...
3 Citations Source Cite
Melinda K. Duncan27
Estimated H-index: 27
(University of Delaware),
Yichen Wang1
Estimated H-index: 1
(University of Delaware)
Zeqian Li (Beijing Technology and Business University), Huan Gu (Beijing Technology and Business University)+ 3 AuthorsJin Lin2
Estimated H-index: 2
AbstractTo improve the efficiency of traditional boiling process, a new high-pressure decocting method was developed for the production of Radix Angelica sinensis (RAS) decoction with higher contents of efficacy components (Z-ligustilide and ferulic acid) and better flavor properties. Based on preliminary tests, a three-level Box–Behnken design was employed to optimise the process parameters, including decocting temperature (120–140°C), decocting time (15–45 min) and liquid/solid ratio (35:1–45:...
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2018 in Acta PhysiologicaIF: 5.93
Yueyuan Wang3
Estimated H-index: 3
(Nanjing Medical University),
Wenjie Deng4
Estimated H-index: 4
(Nanjing Medical University)
+ 6 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Aim MICAL2, a cytoskeleton dynamics regulator, is identified associated with survival and metastasis of several types of cancers recently. The present study was designed to investigate the role of MICAL2 in breast cancer cell migration as well as its underlying mechanisms. Methods The relationship between MICAL2 and EGF/EGFR signaling was analyzed by using gene overexpression and knockdown techniques. Cell migration was measured by wound healing assays. Activation of EGF/EGFR singaling pathways ...
1 Citations Source Cite
2017 in Immunology LettersIF: 2.44
Shirin Eyvazi2
Estimated H-index: 2
(Shahid Beheshti University of Medical Sciences and Health Services),
Bahram Kazemi22
Estimated H-index: 22
(Shahid Beheshti University of Medical Sciences and Health Services)
+ 1 AuthorsSiavoush Dastmalchi17
Estimated H-index: 17
(Tabriz University of Medical Sciences)
Abstract CD24 is a heavy glycosylated protein that is overexpressed in numerous cancer and cancer stem cells. It is involved in the development, invasion, and metastasis of the cancer cells. CD24 can be considered in targeted cancer therapy as a new target. Here, phage display technology was used for the identification of novel scFv antibodies against CD24. To do so, the CD24 protein was expressed and purified from a stable transgenic CHO cell line. The cells were developed by using a CD24 encod...
4 Citations Source Cite
Qin Jiang3
Estimated H-index: 3
(Central South University),
Manyi Yang3
Estimated H-index: 3
(Central South University)
+ 2 AuthorsQi Zhang3
Estimated H-index: 3
(Central South University)
Background The aim of this in vitro study was to measure the enhanced anticancer effects of Res (resveratrol) on PA (paclitaxel) in HepG2 human liver cancer cells.
5 Citations Source Cite
2018 in Cell Death and DiseaseIF: 5.64
Hongwei Xia9
Estimated H-index: 9
(Sichuan University),
Xinyu Dai2
Estimated H-index: 2
(Sichuan University)
+ 6 AuthorsFeng Bi15
Estimated H-index: 15
(Sichuan University)
The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the crosstalk between these two pathways and its implications in targeted therapy remains unclear. We found that the activated EGFR signaling could bypass RhoA to promote the expression of YAP(Yes-associated protein), the core effector of the Hippo signaling, and its downstream target Cyr61. Further studies indicated that EGFR signaling ...
5 Citations Download PDF Cite
2018 in Molecular NeurobiologyIF: 5.08
Thomas Theis2
Estimated H-index: 2
(Rutgers University),
Anmol Singh Johal (Rutgers University)+ 2 AuthorsMelitta Schachner90
Estimated H-index: 90
(Shantou University)
Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at the formation of the neural tube during the second embryonic week in the mouse and peaks during the first postnatal week, its functional relevance is only rudimentarily understood. To gain better insights into the ...
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View next papermiR-455 inhibits cell proliferation and migration via negative regulation of EGFR in human gastric cancer