Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion.
Abstract
Anti-Mullerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal functions. However, the possible extragonadal effects of AMH on the hypothalamic-pituitary-gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH neurons both in mice and humans express the AMH receptor, and that AMH potently activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we show that AMH...
Paper Details
Title
Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion.
Published Date
Jan 12, 2016
Journal
Volume
7
Issue
1
Pages
10055 - 10055
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Notes
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