Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Abstract
Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional regulation and microRNA processing. Mutations in the MECP2 gene are found in 90% of patients with Rett syndrome, a severe developmental disorder with autistic phenotypes. Duplications of MECP2-containing genomic segments cause the MECP2 duplication syndrome, which shares core symptoms with autism spectrum disorders. Although Mecp2-null mice recapitulate most developmental...
Paper Details
Title
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Published Date
Jan 25, 2016
Journal
Volume
530
Issue
7588
Pages
98 - 102
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