Time‐dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell‐derived cardiomyocytes and induced maturation with biomechanical stimulation

Volume: 30, Issue: 4, Pages: 1464 - 1479
Published: Dec 16, 2015
Abstract
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for uncovering disease mechanisms and assessing drugs for efficacy/toxicity. However, the accuracy with which hiPSC-CMs recapitulate the contractile and remodeling signaling of adult cardiomyocytes is not fully known. We used β-adrenergic receptor (β-AR) signaling as a prototype to determine the evolution of signaling component expression and function...
Paper Details
Title
Time‐dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell‐derived cardiomyocytes and induced maturation with biomechanical stimulation
Published Date
Dec 16, 2015
Volume
30
Issue
4
Pages
1464 - 1479
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