Elucidating the role of free polycations in gene knockdown by siRNA polyplexes

Volume: 35, Pages: 248 - 259
Published: Apr 1, 2016
Abstract
Future improvements of non-viral vectors for siRNA delivery require better understanding of intracellular processing and vector interactions with target cells. Here, we have compared the siRNA delivery properties of a lipid derivative of bPEI 1.8kDa (DOPE-PEI) with branched polyethyleneimine (bPEI) with average molecular weights of 1.8kDa (bPEI 1.8kDa) and 25kDa (bPEI 25kDa). We find mechanistic differences between the DOPE-PEI conjugate and...
Paper Details
Title
Elucidating the role of free polycations in gene knockdown by siRNA polyplexes
Published Date
Apr 1, 2016
Volume
35
Pages
248 - 259
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.