Elucidating the role of free polycations in gene knockdown by siRNA polyplexes
Abstract
Future improvements of non-viral vectors for siRNA delivery require better understanding of intracellular processing and vector interactions with target cells. Here, we have compared the siRNA delivery properties of a lipid derivative of bPEI 1.8kDa (DOPE-PEI) with branched polyethyleneimine (bPEI) with average molecular weights of 1.8kDa (bPEI 1.8kDa) and 25kDa (bPEI 25kDa). We find mechanistic differences between the DOPE-PEI conjugate and...
Paper Details
Title
Elucidating the role of free polycations in gene knockdown by siRNA polyplexes
Published Date
Apr 1, 2016
Journal
Volume
35
Pages
248 - 259
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