Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation
Abstract
Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in the CNS after blood-brain barrier disruption, induces encephalitogenic adaptive immune responses and peripheral macrophage...
Paper Details
Title
Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation
Published Date
Sep 10, 2015
Journal
Volume
6
Issue
1
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