Exercise: Is More Always Better?

Published on Feb 1, 2016in Current Biology9.19
· DOI :10.1016/j.cub.2015.12.031
Diana M. Thomas26
Estimated H-index: 26
(MSU: Montclair State University),
Steven B. Heymsfield101
Estimated H-index: 101
(Pennington Biomedical Research Center)
Summary Do greater levels of exercise always promote relatively higher levels of daily energy expenditure and health? Recent studies challenge the traditional assumption that ‘more exercise is better' by suggesting daily energy expenditure and health plateaus are reached beyond which incremental gains are minimal.
  • References (17)
  • Citations (1)
Published on Sep 1, 2014in Obesity3.97
Nicolas D. Knuth7
Estimated H-index: 7
(NIH: National Institutes of Health),
Darcy L. Johannsen16
Estimated H-index: 16
(Pennington Biomedical Research Center)
+ 6 AuthorsKevin D. Hall37
Estimated H-index: 37
(NIH: National Institutes of Health)
Objective To measure resting metabolic rate (RMR) and body composition changes in obese subjects following massive weight loss achieved via bariatric surgery or calorie restriction plus vigorous exercise.
Published on Feb 1, 2016in Current Biology9.19
Herman Pontzer30
Estimated H-index: 30
(CUNY: City University of New York),
Ramon Durazo-Arvizu41
Estimated H-index: 41
(LUC: Loyola University Chicago)
+ 7 AuthorsAmy Luke48
Estimated H-index: 48
(LUC: Loyola University Chicago)
Summary Current obesity prevention strategies recommend increasing daily physical activity, assuming that increased activity will lead to corresponding increases in total energy expenditure and prevent or reverse energy imbalance and weight gain [1–3]. Such Additive total energy expenditure models are supported by exercise intervention and accelerometry studies reporting positive correlations between physical activity and total energy expenditure [4] but are challenged by ecological studies in h...
Published on Nov 10, 2015in JAMA51.27
Thijs M.H. Eijsvogels18
Estimated H-index: 18
(Radboud University Nijmegen),
Paul D. Thompson83
Estimated H-index: 83
(Hartford Hospital)
This Viewpoint discusses evidence that the beneficial effects of physical activity may vary depending on activity levels. Physical inactivity has been labelled a pandemic due to its increasing global prevalence and its health, economic, environmental, and social consequences. More than half of US adults fail to meet the 2008 physical activity recommendations of 30 minutes of moderate-intensity exercise daily (e.g., brisk walking, dancing, and gardening) or 75 minutes of vigorous-intensity exerci...
Published on Oct 1, 2015in Scandinavian Journal of Medicine & Science in Sports3.63
Anna Katarina Melin6
Estimated H-index: 6
(UCPH: University of Copenhagen),
Åsa Tornberg7
Estimated H-index: 7
(Lund University)
+ 6 AuthorsAnders Sjödin29
Estimated H-index: 29
(UCPH: University of Copenhagen)
The female athlete triad (Triad), links low energy availability (EA), with menstrual dysfunction (MD), and impaired bone health. The aims of this study were to examine associations between EA/MD and energy metabolism and the prevalence of Triad-associated conditions in endurance athletes. Forty women [26.2 +/- 5.5 years, body mass index (BMI) 20.6 +/- 2.0 kg/m(2), body fat 20.0 +/- 3.0%], exercising 11.4 +/- 4.5 h/week, were recruited from national teams and competitive clubs. Protocol included ...
Published on Sep 1, 2015in Diabetes Care15.27
Giulia Ferrannini1
Estimated H-index: 1
Thomas Hach8
Estimated H-index: 8
(Boehringer Ingelheim)
+ 3 AuthorsSergio Ghione113
Estimated H-index: 113
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria. Our aim was to analyze this phenomenon quantitatively. RESEARCH DESIGN AND METHODS Eighty-six patients with type 2 diabetes (HbA 1c 7.8 ± 0.8% [62 ± 9 mmol/mol], estimated glomerular filtration rate [eGFR] 89 ± 19 mL ⋅ min −1 ⋅ 1.73 m −2 ) received empagliflozin (25 mg/day) for 90 weeks with frequent ( n = 11) assessments of body weight, eGFR, an...
Published on Jun 24, 2014in Circulation23.05
Michael Dennis Jensen68
Estimated H-index: 68
Donna H. Ryan51
Estimated H-index: 51
+ 16 AuthorsRobert F. Kushner46
Estimated H-index: 46
Harmon S. Jordan, ScD, Karima A. Kendall, PhD, Linda J. Lux, Roycelynn Mentor-Marcel, PhD, MPH, Laura C. Morgan, MA, Michael G. Trisolini, PhD, MBA, Janusz Wnek, PhD Jeffrey L. Anderson, MD, FACC, FAHA, Chair , Jonathan L. Halperin, MD, FACC, FAHA, Chair-Elect , Nancy M. Albert, PhD, CCNS, CCRN,
Published on Apr 1, 2014in British Journal of Sports Medicine11.64
Margo Mountjoy26
Estimated H-index: 26
(McMaster University),
Jorunn Sundgot-Borgen33
Estimated H-index: 33
(Norwegian School of Sport Sciences)
+ 8 AuthorsRichard Budgett11
Estimated H-index: 11
Protecting the health of the athlete is a goal of the International Olympic Committee (IOC). The IOC convened an expert panel to update the 2005 IOC Consensus Statement on the Female Athlete Triad. This Consensus Statement replaces the previous and provides guidelines to guide risk assessment, treatment and return-to-play decisions. The IOC expert working group introduces a broader, more comprehensive term for the condition previously known as ‘Female Athlete Triad’. The term ‘Relative Energy De...
Published on Jan 1, 2014in Nutrition Research and Practice1.71
Jonghoon Park12
Estimated H-index: 12
(Konkuk University),
Ishikawa Takata Kazuko1
Estimated H-index: 1
+ 2 AuthorsJin-Sook Yoon6
Estimated H-index: 6
(KMU: Keimyung University)
The accuracy and noninvasive nature of the doubly labeled water (DLW) method makes it ideal for the study of human energy metabolism in free-living conditions. However, the DLW method is not always practical in many developing and Asian countries because of the high costs of isotopes and equipment for isotope analysis as well as the expertise required for analysis. This review provides information about the theoretical background and practical aspects of the DLW method, including optimal dose, b...
Published on Oct 1, 2012in Obesity Reviews8.19
Diana M. Thomas26
Estimated H-index: 26
(MSU: Montclair State University),
Claude Bouchard133
Estimated H-index: 133
(Pennington Biomedical Research Center)
+ 8 AuthorsKlaas R. Westerterp72
Estimated H-index: 72
(UM: Maastricht University)
Weight loss resulting from an exercise intervention tends to be lower than predicted. Modest weight loss can arise from an increase in energy intake, physiological reductions in resting energy expenditure, an increase in lean tissue or a decrease in non-exercise activity. Lower than expected, weight loss could also arise from weak and invalidated assumptions within predictive models. To investigate these causes, we systematically reviewed studies that monitored compliance to exercise prescriptio...
Paul S. MacLean33
Estimated H-index: 33
Audrey Bergouignan16
Estimated H-index: 16
+ 1 AuthorsMatthew R. Jackman18
Estimated H-index: 18
Dieting is the most common approach to losing weight for the majority of obese and overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself, dieting has a relatively poor success rate for long-term weight reduction. Most obese people eventually regain the weight they have worked so hard to lose. Weight regain has emerged as one of the most significant obstacles for obesity therapeutics, undoubtedly perpetuating the epidemic of excess weight that now affec...
Cited By1
Published on Nov 1, 2016in Applied Physiology, Nutrition, and Metabolism3.46
Michelle Fortier22
Estimated H-index: 22
(U of O: University of Ottawa),
Eva Guérin7
Estimated H-index: 7
Michelle L. Segar2
Estimated H-index: 2
Exercise is medicine (EIM) is grounded in strong evidence regarding the benefits of physical activity. Despite the contributions of EIM initiatives worldwide, rates of physical inactivity remain alarmingly high. We propose a reframe of EIM for the general population to improve motivation and foster sustainable behaviour change. We draw on a solid knowledge-base to explain the value of broadening the nomenclature to physical activity and of promoting a message of well-being via enjoyable physical...
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