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New Developments in Smart Bandage Technologies for Wound Diagnostics.
Published on Jul 1, 2016in Advanced Materials 21.95
· DOI :10.1002/adma.201504829
Anna McLister4
Estimated H-index: 4
(Ulster University),
Jolene McHugh2
Estimated H-index: 2
(Ulster University)
+ 1 AuthorsJames Davis29
Estimated H-index: 29
(Ulster University)
Abstract
The pH of wound fluid has long been recognized as an important diagnostic for assessing wound condition, but as yet there are few technological options available to the clinician. The availability of sensors that can measure wound pH, either in the clinic or at home could significantly improve clinical outcome – particularly in the early identification of complications such as infection. New material designs and electrochemical research strategies that are being targeted at wound diagnostics are identified and a critical overview of emerging research that could be pivotal in setting the direction for future devices is provided.
  • References (51)
  • Cited By (17)
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References51
Published on Jun 25, 2015in Healthcare
Anna McLister4
Estimated H-index: 4
(Ulster University),
James Davis29
Estimated H-index: 29
5 Citations Source Cite
Published on Jan 1, 2008in Nursing times
John Posnett1
Estimated H-index: 1
,
Peter J. Franks1
Estimated H-index: 1
194 Citations
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 1 AuthorsStefan Beckert16
Estimated H-index: 16
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Feb 1, 2010in Proteomics Clinical Applications 3.57
James A. Broadbent7
Estimated H-index: 7
(Queensland University of Technology),
Terry Walsh8
Estimated H-index: 8
(Queensland University of Technology),
Zee Upton30
Estimated H-index: 30
(Queensland University of Technology)
Chronic wounds, such as venous and diabetic leg ulcers, represent a significant health and financial burden to individuals and healthcare systems. In worst-case scenarios this condition may require the amputation of an affected limb, with significant impact on patient quality of life and health. Presently, there are no clinical biochemical analyses used in the diagnosis and management of this condition; moreover few biochemical therapies are accessible to patients. This presents a significant ch...
21 Citations Source Cite
Published on Apr 14, 2008in Sensors and Actuators B-chemical 5.67
Arthur L.P.S. Bailey1
Estimated H-index: 1
(University of Manchester),
Anna Maria Pisanelli11
Estimated H-index: 11
(University of Manchester),
Krishna C. Persaud30
Estimated H-index: 30
A study of conducting polymer sensors for use in monitoring the headspace of metabolites produced from superficial wounds and bums is in progress. Gas chromatography-mass spectrometry (GC-MS) headspace analysis of the most common bacterial species found to be present in wounds has been achieved to determine the key volatile markers for sensor detection. A preliminary study of sensor arrays using seven pure volatiles known to be produced from the bacteria studied is reported [R.A. Allardyce, V.S....
23 Citations Source Cite
Published on Jul 1, 2011in Sensors and Actuators B-chemical 5.67
Qian Li5
Estimated H-index: 5
(South China Normal University),
Hong Li26
Estimated H-index: 26
(South China Normal University)
+ 1 AuthorsZhenghe Xu2
Estimated H-index: 2
(University of Alberta)
Abstract A polymer-based pH electrode has been successfully fabricated via a simple electropolymerization of bisphenol A (BPA) on an indium tin oxide (ITO) electrode using repetitive voltammetric sweeping. A combination of voltammetry, electrochemical impedance spectroscopy and X-ray photoelectron spectroscopy revealed that polybisphenol A (PBPA) films with benzoquinonyl and hydroquinonyl groups not only showed basically reversible redox activities, but also exhibited the mixed ionic–electronic ...
24 Citations Source Cite
Published on Sep 1, 2004in Journal of Solid State Electrochemistry 2.51
Ian Streeter20
Estimated H-index: 20
(University of Oxford),
Henry C. Leventis10
Estimated H-index: 10
(University of Oxford)
+ 5 AuthorsRichard G. Compton85
Estimated H-index: 85
(University of Oxford)
The use of a basal plane pyrolitic graphite electrode immobilised with two redox active species each capable of undergoing a two-electron, two-proton redox process has allowed the development of a sensitive pH probe over a wide pH and temperature range. When the values of the peak potentials of the two processes are combined they shift by ca. 120 mV/pH unit at 25 °C, as measured against two independent, defined reference electrodes.
34 Citations Source Cite
Published on Oct 1, 2011in Archives of Dermatological Research 2.15
Rikke Zillmer1
Estimated H-index: 1
(University of Copenhagen),
Hannah Trøstrup2
Estimated H-index: 2
(University of Copenhagen)
+ 2 AuthorsMagnus S. Ågren22
Estimated H-index: 22
(University of Copenhagen)
Wound fluid collected from chronic wounds may be used as a simple gauge of the processes taking place in the tissue. There is lack of information on the optimal conditions for wound fluid procurement. We have studied possible diurnal variations and duration of wound fluid accumulation using retentive hydrophobic foam on the levels of prototypic cytokines [interleukin (IL)-1α, IL-1β], a chemokine (IL-8) and proteinases [matrix metalloproteinase (MMP)-9] in 23 chronic venous leg ulcer patients. Bi...
13 Citations Source Cite
Published on Jan 1, 2011in Chemical Communications 6.29
Lin Zhou10
Estimated H-index: 10
(University College Cork),
Jeremy D. Glennon32
Estimated H-index: 32
(University College Cork)
+ 4 AuthorsGerard P. McGlacken17
Estimated H-index: 17
(University College Cork)
2-Heptyl-3-hydroxy-4-quinolone, known as the Pseudomonas Quinolone Signal, is a key regulator of bacterial cooperative behaviour known as quorum sensing. A simple electrochemical strategy was employed for its sensitive detection using a bare boron-doped diamond electrode by cyclic voltammetry and amperometry. PQS (and potentially other quinolones) was then detected in cultures of P. aeruginosa pqsL− mutant strains.
22 Citations Source Cite
Published on Nov 1, 2010in Journal of The American Academy of Dermatology 6.90
Stephan Schreml24
Estimated H-index: 24
(University of Regensburg),
Rolf-Markus Szeimies37
Estimated H-index: 37
(University of Regensburg)
+ 2 AuthorsPhilipp Babilas27
Estimated H-index: 27
(University of Regensburg)
Delayed wound healing is one of the major therapeutic and economic issues in medicine today. Cutaneous wound healing is an extremely well-regulated and complex process basically divided into 3 phases: inflammation, proliferation, and tissue remodeling. Unfortunately, we still do not understand this process precisely enough to give direction effectively to impaired healing processes. There have been many new developments in wound healing that provide fascinating insights and may improve our abili...
162 Citations Source Cite
Cited By17
Published on Jul 14, 2016in Journal of Physical Chemistry C 4.48
Layne Bradley3
Estimated H-index: 3
,
George K. Larsen10
Estimated H-index: 10
,
Yiping Zhao47
Estimated H-index: 47
We describe the fabrication and properties of flexible, anisotropic silver nanorod sheets and investigate their potential to function as a sensor. Aligned and tilted silver nanorod (AgNR) arrays are incorporated into polydimethylsiloxane (PDMS) to form flexible conductive sheets. The electrical properties of these sheets are investigated and show large anisotropies, which are related to the alignment direction of the nanorods. Notably, the films show the greatest electrical resistance in the dir...
1 Citations Source Cite
Published on Jan 1, 2016
J. Davis (Ulster University), A. McLister (Ulster University)
The management of chronic wounds places a severe burden on healthcare resources and, with aging populations and an increased prevalence of obesity and diabetes, there have been some extremely pessimistic predictions suggesting substantial increases in the prevalence of pressure, venous, and foot ulcers in the near future. This chapter provides the background to wound management and serves as a foundation for the subsequent discussions. The differences between acute and chronic wounds are conside...
Source Cite
Published on Jan 1, 2016in Journal of Materials Chemistry B 4.78
Giuseppe Tronci12
Estimated H-index: 12
(University of Leeds),
Jie Yin3
Estimated H-index: 3
(University of Leeds)
+ 3 AuthorsDavid J. Wood25
Estimated H-index: 25
(University of Leeds)
The design of exudate-managing wound dressings is an established route to accelerated healing, although such design remains a challenge from material and manufacturing standpoints. Aiming towards the clinical translation of knowledge gained in vitro with highly-swollen rat tail collagen hydrogels, this study investigated the healing capability in a diabetic mouse wound model of telopeptide-free, protease-inhibiting collagen networks. 4-Vinylbenzylation and UV irradiation of type I atelocollagen ...
12 Citations Source Cite
Published on May 4, 2017in Expert Review of Molecular Diagnostics 3.33
Luc Bissonnette15
Estimated H-index: 15
(Laval University),
Michel G. Bergeron51
Estimated H-index: 51
(Laval University)
ABSTRACTIntroduction: Rapidity, simplicity, and portability are highly desirable characteristics of tests and devices designed for performing diagnostics at the point of care (POC), either near patients managed in healthcare facilities or to offer bioanalytical alternatives in external settings. By reducing the turnaround time of the diagnostic cycle, POC diagnostics can reduce the dissemination, morbidity, and mortality of infectious diseases and provide tools to control the global threat of an...
4 Citations Source Cite
Published on Oct 1, 2017in Sensors and Actuators B-chemical 5.67
Guido Panzarasa9
Estimated H-index: 9
(Swiss Federal Laboratories for Materials Science and Technology),
Alina Osypova1
Estimated H-index: 1
(Swiss Federal Laboratories for Materials Science and Technology)
+ 6 AuthorsLuciano F. Boesel8
Estimated H-index: 8
(Swiss Federal Laboratories for Materials Science and Technology)
Abstract Pyranine is a non-toxic fluorescent dye, with a broad range of applications in biomedicine where it allows precise ratiometric detection of pH within the physiological pH window. Hereby, the facile synthesis, potentially interesting for commercial applications, of a novel ion pair between pyranine and benzalkonium is described. Benzalkonium, a quaternary ammonium salt with potent antimicrobial properties, makes pyranine sufficiently hydrophobic to allow its incorporation in conventional...
2 Citations Source Cite
Published on Jul 1, 2017in Advanced materials and technologies
Daisuke Yamamoto2
Estimated H-index: 2
(Osaka Prefecture University),
Shogo Nakata2
Estimated H-index: 2
(Osaka Prefecture University)
+ 3 AuthorsKuniharu Takei10
Estimated H-index: 10
(Osaka Prefecture University)
Flexible healthcare devices attract much research attention due to their potential application in everyday health monitoring and data acquisition. In order to precisely monitor changes in health data, simultaneous recording of motion data is of vital importance, as different modes of human activity have a strong influence on a person's vital signs. However, human motion detection has received comparatively little attention in flexible electronics, even though flexible health monitoring sensors a...
2 Citations Source Cite
Published on Jun 1, 2017in Current Opinion in Electrochemistry
Anna McLister4
Estimated H-index: 4
(Ulster University),
Ashish Mathur4
Estimated H-index: 4
(Amity University),
James Davis29
Estimated H-index: 29
(Ulster University)
Chronic wounds are highly heterogeneous with the complications of tissue remodelling and issues such as infection generating a multitude of molecular and cellular species. It could be anticipated that were information regarding the dynamics of key wound biomarkers available to the clinician, more informed decisions could be implemented to encourage the reinstatement of normal healing processes. There are few diagnostic options available at the time of consultation and the aim of this review has ...
2 Citations Source Cite
Published on Aug 16, 2017in Polymers 2.94
Javad Tavakoli8
Estimated H-index: 8
,
Youhong Tang30
Estimated H-index: 30
Biosensors that detect and convert biological reactions to a measurable signal have gained much attention in recent years. Between 1950 and 2017, more than 150,000 papers have been published addressing the applications of biosensors in different industries, but to the best of our knowledge and through careful screening, critical reviews that describe hydrogel based biosensors for biomedical applications are rare. This review discusses the biomedical application of hydrogel based biosensors, base...
20 Citations Source Cite
Published on Mar 1, 2018in Carbohydrate Polymers 5.16
Honglei Chen3
Estimated H-index: 3
,
Guangqian Lan6
Estimated H-index: 6
+ 6 AuthorsFei Lu5
Estimated H-index: 5
Abstract A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical proper...
14 Citations Source Cite
Given their severity and non-healing nature, diabetic chronic wounds are a significant concern to the 30.3 million Americans diagnosed with diabetes mellitus (2015). Peripheral arterial diseases, neuropathy, and infection contribute to the development of these wounds, which lead to an increased incidence of lower extremity amputations. Early recognition, debridement, offloading, and controlling infection are imperative for timely treatment. However, wound characterization and treatment are highl...
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