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New Developments in Smart Bandage Technologies for Wound Diagnostics

Published on Jul 1, 2016in Advanced Materials 21.95
· DOI :10.1002/adma.201504829
Anna McLister4
Estimated H-index: 4
(Ulster University),
Jolene McHugh2
Estimated H-index: 2
(Ulster University)
+ 1 AuthorsJames Davis30
Estimated H-index: 30
(Ulster University)
Abstract
The pH of wound fluid has long been recognized as an important diagnostic for assessing wound condition, but as yet there are few technological options available to the clinician. The availability of sensors that can measure wound pH, either in the clinic or at home could significantly improve clinical outcome – particularly in the early identification of complications such as infection. New material designs and electrochemical research strategies that are being targeted at wound diagnostics are identified and a critical overview of emerging research that could be pivotal in setting the direction for future devices is provided.
  • References (51)
  • Citations (17)
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References51
Newest
Published on Jul 1, 2015in Electrochemistry Communications 4.66
Petar Kassal1
Estimated H-index: 1
(University of California, San Diego),
Jayoung Kim13
Estimated H-index: 13
(University of California, San Diego)
+ 4 AuthorsJoseph Wang123
Estimated H-index: 123
(University of California, San Diego)
Abstract Advanced wound care technologies need to evolve in response to the growing burden of chronic wounds on national healthcare budgets and the debilitating impact chronic wounds have on patient quality of life. We describe here a new type of smart bandage for determination of uric acid (UA) status, a key wound biomarker, formed by screen printing an amperometric biosensor directly on a wound dressing. Immobilized uricase, paired with a printed catalytic Prussian blue transducer, facilitates...
50 Citations Source Cite
Published on Jun 25, 2015in Healthcare
Anna McLister4
Estimated H-index: 4
(Ulster University),
James Davis30
Estimated H-index: 30
It has been proposed that fluctuations in wound pH can give valuable insights into the healing processes in chronic wounds, but acquiring such data can be a technological challenge especially where there is little sample available. Developments in voltammetric pH sensing have opened up new avenues for the design of probes that can function in ultra-small volumes and can be inherently disposable but, as yet few can meet the demands of wound monitoring. A preliminary investigation of the pH respon...
5 Citations Source Cite
Published on Mar 1, 2014in Sensors and Actuators B-chemical 5.67
Jolene Phair6
Estimated H-index: 6
(Ulster University),
John Benson3
Estimated H-index: 3
(Ulster University)
+ 5 AuthorsJames Davis30
Estimated H-index: 30
(Ulster University)
Butyl grafted polyethylene film loaded with carbon was investigated as a mechanically flexible conductive substrate for electrochemical sensing applications. The electroanalytical properties of the film before and after laser modification and electrochemical anodisation were assessed and its potential application for use in monitoring wound healing critically evaluated using uric acid as a biomarker. The design and development of a prototype smart bandage is detailed and the response to urate ha...
5 Citations Source Cite
Published on Feb 1, 2014in Analytica Chimica Acta 5.12
Meixian Li33
Estimated H-index: 33
(Peking University),
Jolene Phair6
Estimated H-index: 6
(Ulster University)
+ 1 AuthorsJames Davis30
Estimated H-index: 30
(Ulster University)
A carbon fibre probe is described which utilises the oxidation of an endogenous biomarker to provide diagnostic information on the condition of intravascular access lines. The probe surface was modified through anodic oxidation to provide a high selectivity towards urate which was used as a redox probe through which the pH could be determined. A Nernstian response (−60 mV/pH) was obtained which was free from the interference of other redox species common to biofluids. The electroanalytical perfo...
9 Citations Source Cite
Published on Feb 1, 2014in Materials Chemistry and Physics 2.21
Jolene Phair6
Estimated H-index: 6
(Ulster University),
Mayank Joshi1
Estimated H-index: 1
(Ulster University)
+ 2 AuthorsJames Davis30
Estimated H-index: 30
(Ulster University)
Carbon loaded polyethylene films were selected as the base substrate for a mechanically flexible and conductive sensing material for use wound monitoring technologies. The films were processed using laser ablation of the surface to increase the effective surface area of the electrode and then subject to an oxidative electrochemical etch to improve the electron transfer kinetics. The surface morphology of the resulting films was analysed and the electrode performance in relation to monitoring uri...
9 Citations Source Cite
Published on Oct 9, 2013in ACS Applied Materials & Interfaces 8.10
James Davis30
Estimated H-index: 30
,
María Teresa Molina1
Estimated H-index: 1
+ 1 AuthorsMarco F. Cardosi18
Estimated H-index: 18
Atmospheric plasma treated carbon fiber filaments (10 micron) were used as the base substrate in the design of a probe intended for use within intravascular access devices. The microfiber probe was further functionalized with a polyplumbagin layer through which the line pH could be determined voltammetrically and therein provide the potential for obtaining diagnostic information relating to bacterial colonization of the line. The redox processes attributed to the immobilized polymer are characte...
6 Citations Source Cite
Published on Aug 1, 2013in Electrochemistry Communications 4.66
Jolene Phair6
Estimated H-index: 6
(Ulster University),
James Davis30
Estimated H-index: 30
(Ulster University)
+ 1 AuthorsMarco F. Cardosi18
Estimated H-index: 18
Atmospheric pressure plasma processing has been investigated as a rapid means of activating carbon fibre thread for use in the manufacture of smart bandages. Ferrocyanide and ruthenium hexamine were used as redox probes to assess the influence of plasma exposure time on the electroanalytical performance of material to be incorporated within prototype wound dressings. Ion exchange of the ruthenium at the carbon interface was observed and was attributed to the plasma induced creation of surface ca...
9 Citations Source Cite
Published on Jul 1, 2013in Acta Biomaterialia 6.38
Liane Moura10
Estimated H-index: 10
(University of Coimbra),
Ana M.A. Dias23
Estimated H-index: 23
(University of Coimbra)
+ 1 AuthorsHermínio C. de Sousa25
Estimated H-index: 25
(University of Coimbra)
Diabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, o...
209 Citations Source Cite
Markus Loeffler77
Estimated H-index: 77
(University of Tübingen),
Heiko Schuster13
Estimated H-index: 13
(University of Tübingen)
+ 1 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Mar 1, 2013in Biosensors and Bioelectronics 8.17
Tim R. Dargaville21
Estimated H-index: 21
(Queensland University of Technology),
Brooke L. Farrugia12
Estimated H-index: 12
(Queensland University of Technology)
+ 3 AuthorsH VoelckerNicolas45
Estimated H-index: 45
(University of South Australia)
Abstract Wound healing involves a complex series of biochemical events and has traditionally been managed with ‘low tech’ dressings and bandages. The concept that diagnostic and theranostic sensors can complement wound management is rapidly growing in popularity as there is tremendous potential to apply this technology to both acute and chronic wounds. Benefits in sensing the wound environment include reduction of hospitalization time, prevention of amputations and better understanding of the pr...
155 Citations Source Cite
Cited By17
Newest
Published on Jan 17, 2019in Sensors 2.48
Maria Cuartero11
Estimated H-index: 11
,
Marc Parrilla6
Estimated H-index: 6
,
Gastón A. Crespo23
Estimated H-index: 23
Wearable potentiometric sensors have received considerable attention owing to their great potential in a wide range of physiological and clinical applications, particularly involving ion detection in sweat. Despite the significant progress in the manner that potentiometric sensors are integrated in wearable devices, in terms of materials and fabrication approaches, there is yet plenty of room for improvement in the strategy adopted for the sample collection. Essentially, this involves a fluidic ...
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Published on Jan 1, 2019in Materials Science and Engineering: C 5.08
Mingzhuo Liu1
Estimated H-index: 1
(Nanchang University),
Huiqing Zhang1
Estimated H-index: 1
(Nanchang University)
+ 6 AuthorsXiaolei Wang23
Estimated H-index: 23
(Nanchang University)
Abstract Scald first-aid needs to reduce the local temperature as well as the bacterial colonization. Bacteria resistant problem has become a major challenge that global public health workers face. Long-term and high dosage use of antibacterial agents is the main reason. In this study, temperature-regulated release antibacterial nanoparticles were applied to poly(n-isopropyl acrylamide) and sodium polyacrylate. This hypothermia coverage could be used as an ideal scald first-aid wound dressing wi...
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Published on Jan 1, 2019in Trends in Analytical Chemistry 7.03
Marc Parrilla6
Estimated H-index: 6
(Royal Institute of Technology),
María Cuartero2
Estimated H-index: 2
(Royal Institute of Technology),
Gastón A. Crespo23
Estimated H-index: 23
(Royal Institute of Technology)
Abstract Wearable potentiometric ion sensors (WPISs) have become an exciting analytical platform that combines chemical, material and electronic efforts to supply physiological information during certain human activities. The real possibility of wearing an analytical device with diverse configurations—sweatband, patches, garments—without disturbing the welfare of the carrier has enabled potentiometric ion sensors both as health quality and sport performance controllers. Recent studies show a lar...
3 Citations Source Cite
Published on Oct 1, 2018in Biosensors and Bioelectronics 8.17
Aniket Pal2
Estimated H-index: 2
(Purdue University),
Debkalpa Goswami5
Estimated H-index: 5
(Purdue University)
+ 3 AuthorsRamses V. Martinez21
Estimated H-index: 21
(Purdue University)
Abstract The growing socio-economic burden of chronic skin wounds requires the development of new automated and non-invasive analytical systems capable of wirelessly monitoring wound status. This work describes the low-cost fabrication of single-use, omniphobic paper-based smart bandages (OPSBs) designed to monitor the status of open chronic wounds and to detect the formation of pressure ulcers. OPSBs are lightweight, flexible, breathable, easy to apply, and disposable by burning. A reusable wea...
5 Citations Source Cite
Published on Oct 1, 2018in Advanced Science 12.44
Mehdi Mehrali29
Estimated H-index: 29
(Technical University of Denmark),
Sara Bagherifard20
Estimated H-index: 20
(Polytechnic University of Milan)
+ 9 AuthorsJenny Emnéus35
Estimated H-index: 35
(Technical University of Denmark)
At the crossroads of chemistry, electronics, mechanical engineering, polymer science, biology, tissue engineering, computer science, and materials science, electrical devices are currently being engineered that blend directly within organs and tissues. These sophisticated devices are mediators, recorders, and stimulators of electricity with the capacity to monitor important electrophysiological events, replace disabled body parts, or even stimulate tissues to overcome their current limitations. ...
1 Citations Source Cite
Published on Jun 26, 2018in Bioengineering
Elizabeth Gianino1
Estimated H-index: 1
,
Craig Miller1
Estimated H-index: 1
,
Jordon Gilmore2
Estimated H-index: 2
Given their severity and non-healing nature, diabetic chronic wounds are a significant concern to the 30.3 million Americans diagnosed with diabetes mellitus (2015). Peripheral arterial diseases, neuropathy, and infection contribute to the development of these wounds, which lead to an increased incidence of lower extremity amputations. Early recognition, debridement, offloading, and controlling infection are imperative for timely treatment. However, wound characterization and treatment are highl...
1 Citations Source Cite
Published on Mar 1, 2018in Carbohydrate Polymers 5.16
Honglei Chen3
Estimated H-index: 3
(Southwest University),
Guangqian Lan7
Estimated H-index: 7
(Southwest University)
+ 6 AuthorsFei Lu5
Estimated H-index: 5
(Southwest University)
Abstract A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical proper...
21 Citations Source Cite
Published on Jan 1, 2018
Liis Preem2
Estimated H-index: 2
(University of Tartu),
Karin Kogermann15
Estimated H-index: 15
(University of Tartu)
Antimicrobial drug-loaded electrospun nano-/microfibrous mats are of major interest as wound dressings for effective wound care. Treatment of wound infection is a crucial part of the therapy, and high bioburden leading to persistent infections and systemic toxicity are an increasing antibiotic-related problems. It is evident that biofilm plays a significant role in the development of hard-to-heal chronic wounds, and therefore novel strategies to fight against microbial biofilms are of relevance....
1 Citations Source Cite
Published on Jan 1, 2018in Journal of Materials Chemistry B 4.78
Jian Zhao2
Estimated H-index: 2
(Shaanxi Normal University),
Yangcui Qu6
Estimated H-index: 6
(Soochow University (Taiwan))
+ 3 AuthorsPeng Yang2
Estimated H-index: 2
(Shaanxi Normal University)
A new type of wound dressing that can be easily peeled from a wound during frequent changes is essential in clinical applications to reduce secondary trauma and relieve the pain suffered by patients. Here, we discover that a phase-transitioned lysozyme nanofilm (PTLF) composed of self-assembled protein nanoparticles with an amyloid-like internal structure can be disassembled and detached from a substrate surface under the stimulus of vitamin C solution. Accordingly, stimuli-responsive gauze coat...
4 Citations Source Cite
Published on Oct 1, 2017in Sensors and Actuators B-chemical 5.67
Guido Panzarasa9
Estimated H-index: 9
(Swiss Federal Laboratories for Materials Science and Technology),
Alina Osypova3
Estimated H-index: 3
(Swiss Federal Laboratories for Materials Science and Technology)
+ 6 AuthorsLuciano F. Boesel8
Estimated H-index: 8
(Swiss Federal Laboratories for Materials Science and Technology)
Abstract Pyranine is a non-toxic fluorescent dye, with a broad range of applications in biomedicine where it allows precise ratiometric detection of pH within the physiological pH window. Hereby, the facile synthesis, potentially interesting for commercial applications, of a novel ion pair between pyranine and benzalkonium is described. Benzalkonium, a quaternary ammonium salt with potent antimicrobial properties, makes pyranine sufficiently hydrophobic to allow its incorporation in conventional...
3 Citations Source Cite