The evolutionary turnover of recombination hot spots contributes to speciation in mice
Abstract
Meiotic recombination is required for the segregation of homologous chromosomes and is essential for fertility. In most mammals, the DNA double-strand breaks (DSBs) that initiate meiotic recombination are directed to a subset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 protein. Rapid evolution of the DNA-binding specificity of PRDM9 and gradual erosion of PRDM9-binding sites by gene conversion will alter the...
Paper Details
Title
The evolutionary turnover of recombination hot spots contributes to speciation in mice
Published Date
Feb 1, 2016
Journal
Volume
30
Issue
3
Pages
266 - 280
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