Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining

Volume: 113, Issue: 5, Pages: 1256 - 1260
Published: Feb 2, 2016
Abstract
In eukaryotes, DNA double-strand breaks (DSBs), one of the most harmful types of DNA damage, are repaired by homologous repair (HR) and nonhomologous end-joining (NHEJ). Surprisingly, in cells deficient for core classic NHEJ factors such as DNA ligase IV (Lig4), substantial end-joining activities have been observed in various situations, suggesting the existence of alternative end-joining (A-EJ) activities. Several putative A-EJ factors have...
Paper Details
Title
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining
Published Date
Feb 2, 2016
Volume
113
Issue
5
Pages
1256 - 1260
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