Usefulness of Screening for Paroxismal Nocturnal Hemoglobinuria in Patients with Undefined Anemia

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare life-threatening blood disease that is characterized by intravascular hemolytic anemia and thrombosis. It may be primary or secondary to other bone marrow diseases. It results from clonal expansion of a multipotent hematolopoietic stem cell harboring a PIG-A mutation. The PIG-A gene product is required for the biosynthesis of glycophosphatidylinositol anchors, a glycolipid moiety...