Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?
Abstract
The gut epithelium is covered by mucus consisting of mucin polymers connected via disulfide bonds. The mucus layer limits exposure of epithelial cells to toxins and bacteria. A recent study has shown that sulfide, produced by certain bacteria, reduces disulfide bonds in the mucus network. The resulting breaks in the mucus barrier allow exposure of the epithelium to bacteria and toxins, causing inflammation. In this opinion article we argue that...
Paper Details
Title
Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?
Published Date
Mar 1, 2016
Journal
Volume
22
Issue
3
Pages
190 - 199
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