Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

Tinnitus, prevalent in up to 15% of the world population, is typically linked to noise-associated hearing loss, but the relationship between noise exposure and tinnitus is not straightforward: not all humans or model animals develop tinnitus after noise-associated cochlear damage, and the mechanisms involved in tinnitus involve central auditory system and nonauditory brain areas. This Review provides an overview of current understanding of...