Efeitos da sibutramina no tratamento da obesidade em pacientes com hipertensão arterial

Published on Feb 1, 2002in Arquivos Brasileiros De Cardiologia 1.32
Alessandra Nunes Faria10
Estimated H-index: 10
,
Fernando Flexa Ribeiro Filho8
Estimated H-index: 8
+ 3 AuthorsMaria Teresa Zanella20
Estimated H-index: 20
Abstract
OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7 percent versus 2.5 percent; p
  • References (0)
  • Citations (12)
References0
  • References (0)
  • Citations (12)
Cited By12
Published on Aug 1, 2008in Expert Opinion on Pharmacotherapy 3.48
Bikash Sharma7
Estimated H-index: 7
,
David Henderson47
Estimated H-index: 47
Background: Obesity has become a global epidemic with recent estimates of > 400 million obese adults. Despite this, there are few safe and effective pharmacological interventions for obesity. Sibutramine is a weight loss agent, for use as an adjuvant to a comprehensive program of calorie restriction, exercise and behavioral therapy. Objective: The goal of this article is to review the available literature of pharmacological interventions for obesity and specifically to examine data with sibutram...
22 Citations Source Cite
Published on Nov 1, 2008in Sao Paulo Medical Journal 1.06
Hernani Pinto de Lemos Júnior4
Estimated H-index: 4
(Federal University of São Paulo),
Álvaro Nagib Atallah34
Estimated H-index: 34
(Federal University of São Paulo),
André Luis Alves de Lemos1
Estimated H-index: 1
(Federal University of São Paulo)
CONTEXTO: Hipertensao arterial sistemica e parte da sindrome metabolica relacionada a obesidade. OBJETIVO: Avaliar o efeito da sibutramina na pressao arterial sistemica de pacientes com sobrepeso e obesos atraves de uma revisao sistematica. METODOS: Tipos de estudos: todos os estudos devem ser controlados e aleatorios. A qualidade metodologica dos estudos selecionados foi acessada usando os criterios descritos no Cochrane Handbook; participantes: pacientes com sobrepeso e obesos; intervencao: si...
7 Citations Source Cite
Published on Jun 1, 2013in American Journal of Cardiovascular Drugs 2.74
Srividya Kidambi12
Estimated H-index: 12
(Medical College of Wisconsin),
Theodore A. Kotchen48
Estimated H-index: 48
(Medical College of Wisconsin)
Obesity is a global pandemic and with its rise, its associated co-morbidities are increasing in prevalence, particularly uncontrolled hypertension. Lifestyle changes should be an anchor for the management of obesity-related hypertension; however, they are difficult to sustain. Drug therapy is often necessary to achieve blood pressure control. Diuretics, inhibitors of the renin–angiotensin system, and dihydropyridine calcium channel blockers are often used as first trio, with subsequent additions...
8 Citations Source Cite
Eduardo Cantoni Rosa7
Estimated H-index: 7
,
Maria Tereza Zanella9
Estimated H-index: 9
+ 4 AuthorsOsvaldo Kohlmann12
Estimated H-index: 12
OBJECTIVE: Blood pressure(BP) and target organ responses to antihypertensive drugs are not well established in hypertensive obese patients. This study is aimed at evaluating the effects of obesity and adiposity distribution patterns on these responses. METHODS: 49 hypertensive obese women were designated to different groups according to waist to hip ratio measurements - 37 with troncular and 12 with peripheral obesity. Patients were treated for 24-weeks on a stepwise regimen with cilazapril alon...
4 Citations Source Cite
Published on Sep 1, 2003in Obesity Research
Su Hyun Kim3
Estimated H-index: 3
(Yonsei University),
Young-Mee Lee10
Estimated H-index: 10
(Korea University)
+ 1 AuthorsChung Mo Nam32
Estimated H-index: 32
(Yonsei University)
Objective: Sibutramine causes weight loss by suppressing the appetite and by promoting energy expenditure, but it can also increase blood pressure through a norepinephrine effect. The aim of this study was to provide a comprehensive meta-analysis of randomized, controlled trials on the effects of sibutramine on blood pressure and weight loss. Research Methods and Procedures: Twenty-one placebo-controlled, double-blind, randomized trials of sibutramine were identified using MEDLINE, EMBASE, and a...
88 Citations Source Cite
Published on May 1, 2005in Diabetes, Obesity and Metabolism 5.98
Alessandra Nunes Faria10
Estimated H-index: 10
(Federal University of São Paulo),
F. F. Ribeiro Filho1
Estimated H-index: 1
(Federal University of São Paulo)
+ 2 AuthorsM. T. Zanella10
Estimated H-index: 10
(Federal University of São Paulo)
Objective: The objective of this study is to assess the effects of sibutramine on body weight, body fat distribution, insulin resistance, plasma leptin, lipid profile and blood pressure profiles in hypertensive obese patients. Methods: Eighty-six central obese hypertensive patients (BMI = 39 ± 5 kg/m2, 84% of women, 48 ± 8.5 years old) were placed on a hypocaloric diet and placebo therapy for 4 weeks. They were then randomized to receive sibutramine (10 mg) or placebo for 24 weeks. Both, before ...
24 Citations Source Cite
Published on May 10, 2004in JAMA Internal Medicine 19.99
David Arterburn28
Estimated H-index: 28
,
Paul K. Crane57
Estimated H-index: 57
(University of Washington),
David L. Veenstra41
Estimated H-index: 41
(University of Washington)
Background The primary goal of weight loss is to prevent or reduce obesity-associated morbidity and mortality by improving cardiovascular and metabolic risk factors. We conducted a systematic review to assess the efficacy and safety of sibutramine hydrochloride for weight loss. Methods In April 2002, we searched MEDLINE, EMBASE, the Cochrane Library, and 7 other computerized bibliographic search tools using the keywords "sibutramine," "Meridia," and "Reductil" (in all languages and all available...
212 Citations Source Cite
Published on Jul 8, 2009in Cochrane Database of Systematic Reviews 6.75
Andrea Siebenhofer24
Estimated H-index: 24
(Goethe University Frankfurt),
Klaus Jeitler14
Estimated H-index: 14
(Medical University of Graz)
+ 6 AuthorsKarl Horvath15
Estimated H-index: 15
(Medical University of Graz)
Background All major guidelines for antihypertensive therapy recommend weight loss. Thus dietary interventions that aim to reduce body weight might be a useful intervention to reduce blood pressure and adverse cardiovascular events associated with hypertension. Objectives Primary objectives To assess the long-term effects of weight-reducing diets in hypertensive patients on - all cause mortality - cardiovascular morbidity - adverse events (including total serious adverse events, withdrawal due t...
98 Citations Source Cite
Published on Mar 24, 2008in JAMA Internal Medicine 19.99
Karl Horvath15
Estimated H-index: 15
,
Klaus Jeitler14
Estimated H-index: 14
+ 4 AuthorsAndrea Siebenhofer24
Estimated H-index: 24
Weight loss is recommended in all major guidelines for antihypertensive therapy. We searched for randomized controlled trials investigating the effects of weightreducing diets, pharmacologic substances, and invasive interventions for weight reduction on patient-relevant end points and blood pressure (BP) in patients with essential hypertension. No information on the effects on patient-relevant end points was available. Patients assigned to weight loss diets, orlistat, or sibutramine reduced thei...
94 Citations Source Cite
Published on Mar 2, 2016in Cochrane Database of Systematic Reviews 6.75
Andrea Siebenhofer24
Estimated H-index: 24
(Medical University of Graz),
Klaus Jeitler14
Estimated H-index: 14
(Medical University of Graz)
+ 4 AuthorsThomas Semlitsch10
Estimated H-index: 10
(Medical University of Graz)
Background All major guidelines for antihypertensive therapy recommend weight loss. Thus dietary interventions that aim to reduce body weight might be a useful intervention to reduce blood pressure and adverse cardiovascular events associated with hypertension. Objectives Primary objectives To assess the long-term effects of weight-reducing diets in people with hypertension on all-cause mortality, cardiovascular morbidity, and adverse events (including total serious adverse events, withdrawal du...
25 Citations Source Cite
Are you a researcher?
Try search on the fastest academic search engine.