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Efeitos da sibutramina no tratamento da obesidade em pacientes com hipertensão arterial

Published on Feb 1, 2002in Arquivos Brasileiros De Cardiologia 1.68
Alessandra Nunes Faria10
Estimated H-index: 10
,
Fernando Flexa Ribeiro Filho8
Estimated H-index: 8
+ 3 AuthorsMaria Teresa Zanella19
Estimated H-index: 19
Abstract
OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7 percent versus 2.5 percent; p
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Published on Nov 29, 2016in Cochrane Database of Systematic Reviews 7.75
Emma Mead7
Estimated H-index: 7
(Teesside University),
Gregory Atkinson16
Estimated H-index: 16
(Teesside University)
+ 6 AuthorsLouisa Ells15
Estimated H-index: 15
(Teesside University)
Background Child and adolescent obesity has increased globally, and can be associated with significant short- and long-term health consequences. Objectives To assess the efficacy of drug interventions for the treatment of obesity in children and adolescents. Search methods We searched CENTRAL, MEDLINE, Embase, PubMed (subsets not available on Ovid), LILACS as well as the trial registers ICTRP (WHO) and ClinicalTrials.gov. Searches were undertaken from inception to March 2016. We checked referenc...
19 Citations Source Cite
Published on Sep 30, 2016
Antonio Edson Magalhaes Camelo , Caroline Matias Nascimento Dinelly (INTA: International Trademark Association), Maria Auxiliadora Silva Oliveira1
Estimated H-index: 1
(UFC: Federal University of Ceará)
Objetivou-se tracar um perfil das prescricoes de medicamentos psicotropicos (anorexigenos, antidepressivos e benzodiazepinicos) a partir de revisao. Para isso foi realizado uma pesquisa de natureza bibliografica, descritiva, retrospectiva utilizando como base de dados bibliotecas virtuais LILACS, BIREME, Scientific Library on Line (SciELO), Google, alem dos documentos, artigo e dados publicados pelo Ministerio da Saude e ANVISA. Os resultados encontrados foram: os anorexigenos mais prescritos an...
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Published on Mar 2, 2016in Cochrane Database of Systematic Reviews 7.75
Andrea Siebenhofer24
Estimated H-index: 24
(Medical University of Graz),
Klaus Jeitler14
Estimated H-index: 14
(Medical University of Graz)
+ 4 AuthorsThomas Semlitsch10
Estimated H-index: 10
(Medical University of Graz)
Background All major guidelines for antihypertensive therapy recommend weight loss. Thus dietary interventions that aim to reduce body weight might be a useful intervention to reduce blood pressure and adverse cardiovascular events associated with hypertension. Objectives Primary objectives To assess the long-term effects of weight-reducing diets in people with hypertension on all-cause mortality, cardiovascular morbidity, and adverse events (including total serious adverse events, withdrawal du...
26 Citations Source Cite
Published on Jun 1, 2013in American Journal of Cardiovascular Drugs 2.58
Srividya Kidambi12
Estimated H-index: 12
(MCW: Medical College of Wisconsin),
Theodore A. Kotchen48
Estimated H-index: 48
(MCW: Medical College of Wisconsin)
Obesity is a global pandemic and with its rise, its associated co-morbidities are increasing in prevalence, particularly uncontrolled hypertension. Lifestyle changes should be an anchor for the management of obesity-related hypertension; however, they are difficult to sustain. Drug therapy is often necessary to achieve blood pressure control. Diuretics, inhibitors of the renin–angiotensin system, and dihydropyridine calcium channel blockers are often used as first trio, with subsequent additions...
8 Citations Source Cite
Published on Jul 8, 2009in Cochrane Database of Systematic Reviews 7.75
Andrea Siebenhofer24
Estimated H-index: 24
(Goethe University Frankfurt),
Klaus Jeitler14
Estimated H-index: 14
(Medical University of Graz)
+ 6 AuthorsKarl Horvath15
Estimated H-index: 15
(Medical University of Graz)
Background All major guidelines for antihypertensive therapy recommend weight loss. Thus dietary interventions that aim to reduce body weight might be a useful intervention to reduce blood pressure and adverse cardiovascular events associated with hypertension. Objectives Primary objectives To assess the long-term effects of weight-reducing diets in hypertensive patients on - all cause mortality - cardiovascular morbidity - adverse events (including total serious adverse events, withdrawal due t...
99 Citations Source Cite
Published on Nov 1, 2008in Sao Paulo Medical Journal 1.09
Hernani Pinto de Lemos Júnior4
Estimated H-index: 4
(UNIFESP: Federal University of São Paulo),
Álvaro Nagib Atallah34
Estimated H-index: 34
(UNIFESP: Federal University of São Paulo),
André Luis Alves de Lemos2
Estimated H-index: 2
(UNIFESP: Federal University of São Paulo)
CONTEXTO: Hipertensao arterial sistemica e parte da sindrome metabolica relacionada a obesidade. OBJETIVO: Avaliar o efeito da sibutramina na pressao arterial sistemica de pacientes com sobrepeso e obesos atraves de uma revisao sistematica. METODOS: Tipos de estudos: todos os estudos devem ser controlados e aleatorios. A qualidade metodologica dos estudos selecionados foi acessada usando os criterios descritos no Cochrane Handbook; participantes: pacientes com sobrepeso e obesos; intervencao: si...
7 Citations Source Cite
Published on Aug 1, 2008in Expert Opinion on Pharmacotherapy 3.04
Bikash Sharma7
Estimated H-index: 7
,
David Henderson46
Estimated H-index: 46
Background: Obesity has become a global epidemic with recent estimates of > 400 million obese adults. Despite this, there are few safe and effective pharmacological interventions for obesity. Sibutramine is a weight loss agent, for use as an adjuvant to a comprehensive program of calorie restriction, exercise and behavioral therapy. Objective: The goal of this article is to review the available literature of pharmacological interventions for obesity and specifically to examine data with sibutram...
22 Citations Source Cite
Published on Mar 24, 2008in JAMA Internal Medicine 20.77
Karl Horvath15
Estimated H-index: 15
,
Klaus Jeitler14
Estimated H-index: 14
+ 4 AuthorsAndrea Siebenhofer24
Estimated H-index: 24
Weight loss is recommended in all major guidelines for antihypertensive therapy. We searched for randomized controlled trials investigating the effects of weightreducing diets, pharmacologic substances, and invasive interventions for weight reduction on patient-relevant end points and blood pressure (BP) in patients with essential hypertension. No information on the effects on patient-relevant end points was available. Patients assigned to weight loss diets, orlistat, or sibutramine reduced thei...
94 Citations Source Cite
Eduardo Cantoni Rosa7
Estimated H-index: 7
,
Maria Tereza Zanella12
Estimated H-index: 12
+ 4 AuthorsOsvaldo Kohlmann15
Estimated H-index: 15
OBJECTIVE: Blood pressure(BP) and target organ responses to antihypertensive drugs are not well established in hypertensive obese patients. This study is aimed at evaluating the effects of obesity and adiposity distribution patterns on these responses. METHODS: 49 hypertensive obese women were designated to different groups according to waist to hip ratio measurements - 37 with troncular and 12 with peripheral obesity. Patients were treated for 24-weeks on a stepwise regimen with cilazapril alon...
4 Citations Source Cite
Published on May 1, 2005in Diabetes, Obesity and Metabolism 6.13
Alessandra Nunes Faria10
Estimated H-index: 10
(UNIFESP: Federal University of São Paulo),
F. F. Ribeiro Filho1
Estimated H-index: 1
(UNIFESP: Federal University of São Paulo)
+ 2 AuthorsM. T. Zanella11
Estimated H-index: 11
(UNIFESP: Federal University of São Paulo)
Objective: The objective of this study is to assess the effects of sibutramine on body weight, body fat distribution, insulin resistance, plasma leptin, lipid profile and blood pressure profiles in hypertensive obese patients. Methods: Eighty-six central obese hypertensive patients (BMI = 39 ± 5 kg/m2, 84% of women, 48 ± 8.5 years old) were placed on a hypocaloric diet and placebo therapy for 4 weeks. They were then randomized to receive sibutramine (10 mg) or placebo for 24 weeks. Both, before ...
24 Citations Source Cite