Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Published: Feb 11, 2015
Abstract
The central role of hydroxyprostaglandin dehydrogenase(HPGD) is to inactivate prostaglandins such as prostaglandin E2 (PGE2) or prostaglandin D2 (PGD2). These prostaglandins are involved in a number of processes, including inflammation, differentiation, and cellular signaling, which makes HPGD an important target for pharmacological intervention. High throughput screening of the Molecular Libraries Small Molecule Repository (MLSMR) led to the...
Paper Details
Title
Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Published Date
Feb 11, 2015
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