Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins
Abstract
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). This interaction occurs primarily via a conserved motif termed the LC3-interacting region (LIR), or the Atg8-interacting motif (AIM). The consensus sequence for this motif, [W/F/Y]xx[L/I/V], can be found in many proteins, but only some of them are...
Paper Details
Title
Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins
Published Date
Dec 1, 2015
Journal
Volume
11
Issue
12
Pages
2153 - 2159
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