Role of the RANK/RANKL pathway in breast cancer
Abstract
The discovery of the OPG/RANK/RANKL pathway two decades ago has initiated novel insights into regulation of bone formation. More recently this pathway has been found to be also relevant in osteoclastic-independent mechanisms, mainly in mammary physiology and breast cancer. RANKL/RANK function is essential for epithelial cell proliferation and cellular survival as well as lobulo-alveolar development. The endogenous OPG functions as a soluble...
Paper Details
Title
Role of the RANK/RANKL pathway in breast cancer
Published Date
Apr 1, 2016
Journal
Volume
86
Pages
10 - 16
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