Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure–Activity Relationship Study

Volume: 58, Issue: 18, Pages: 7310 - 7327
Published: Sep 4, 2015
Abstract
A series of novel C,N-cyclometalated benzimidazole ruthenium(II) and iridium(III) complexes of the types [(η6-p-cymene)RuCl(κ2-N,C-L)] and [(η5-C5Me5)IrCl(κ2-N,C-L)] (HL = methyl 1-butyl-2-arylbenzimidazolecarboxylate) with varying substituents (H, Me, F, CF3, MeO, NO2, and Ph) in the R4 position of the phenyl ring of 2-phenylbenzimidazole chelating ligand of the ruthenium (3a–g) and iridium complexes (4a–g) have been prepared. The cytotoxic...
Paper Details
Title
Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure–Activity Relationship Study
Published Date
Sep 4, 2015
Volume
58
Issue
18
Pages
7310 - 7327
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