Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
Abstract
Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly and no effective treatment is currently available. The mechanisms triggering AD onset and progression are still imperfectly dissected. We aimed at deciphering the modifications occurring in vivo during the very early stages of AD, before the development of amyloid deposits, neurofibrillary tangles, neuronal death and inflammation. Most current AD models based on...
Paper Details
Title
Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
Published Date
Jan 12, 2016
Journal
Volume
11
Issue
1
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