LRRK2BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function
Abstract
Mutations in leucine-rich repeat kinase 2 (LRRK2) lead to late-onset, autosomal dominant Parkinson's disease, characterized by the degeneration of dopamine neurons of the substantia nigra pars compacta, a deficit in dopamine neurotransmission and the development of motor and non-motor symptoms. The most prevalent Parkinson's disease LRRK2 mutations are located in the kinase (G2019S) and GTPase (R1441C) encoding domains of LRRK2. To better...
Paper Details
Title
LRRK2BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function
Published Date
Jan 6, 2016
Journal
Volume
25
Issue
5
Pages
951 - 963
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Notes
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