Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Abstract
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH), respectively. The discovery of BRAFV600E mutations in approximately 50% of these patients provided the first molecular therapeutic target in histiocytosis. However, recurrent driving mutations in the majority...
Paper Details
Title
Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Published Date
Feb 1, 2016
Journal
Volume
6
Issue
2
Pages
154 - 165
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History