Original paper
Development of a targeted selected ion monitoring assay for the elucidation of protease induced structural changes in cardiac troponin T
Abstract
Cardiac troponin T (cTnT) is a highly cardiospecific protein commonly used in the diagnosis of acute myocardial infarction (AMI), but is subject to proteolytic degradation upon its release in the circulation. In this study, a targeted mass spectrometry assay was developed to detect peptides which are differentially present within the different degradation products. cTnT was spiked in human serum and incubated at 37 °C to induce proteolytic...
Paper Details
Title
Development of a targeted selected ion monitoring assay for the elucidation of protease induced structural changes in cardiac troponin T
Published Date
Mar 1, 2016
Journal
Volume
136
Pages
123 - 132
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Notes
History