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Reducing progression of knee OA features assessed by MRI in overweight and obese women: secondary outcomes of a preventive RCT.

Published on Jun 1, 2016in Osteoarthritis and Cartilage4.88
· DOI :10.1016/j.joca.2015.12.016
M.L. Landsmeer2
Estimated H-index: 2
(EUR: Erasmus University Rotterdam),
J. Runhaar11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam)
+ 6 AuthorsSita M. A. Bierma-Zeinstra68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
Cite
Abstract
Summary Objective To evaluate the preventive effects of a randomized controlled trial on progression of Magnetic Resonance Imaging (MRI) features of knee osteoarthritis (OA) in overweight and obese women. Design In a 2 × 2 factorial design, 2.5 years effects of a diet and exercise program and of glucosamine sulphate (double-blind, placebo-controlled) were evaluated in 407 middle-aged women with body mass index (BMI) ≥ 27 kg/m 2 without clinical signs of knee OA at baseline (ISRCTN 42823086). MRIs were scored with the MRI Osteoarthritis Knee Score (MOAKS). Progression was defined for bone marrow lesions (BMLs), cartilage defects, osteophytes, meniscal abnormalities and meniscal extrusion. Analyses on knee level were performed over the four intervention groups using adjusted Generalized Estimating Equations (GEE). Results 687 knees of 347 women with mean age 55.7 years (±3.2 SD) and mean BMI 32.3 kg/m 2 (±4.2 SD) were analyzed. Baseline prevalence was 64% for BMLs, 70% for cartilage defects, 24% for osteophytes, 66% for meniscal abnormalities and 52% for meniscal extrusions. The diet and exercise program + placebo intervention showed significantly less progression of meniscal extrusion compared to placebo only (12% vs 22%, OR 0.50, 95% CI [0.27–0.92]). The interventions did not result in significant differences on other OA MRI features. Conclusions In subjects at high risk for future knee OA development, a diet and exercise program, glucosamine sulphate and their combination showed small and mainly non-significant effects on the progression of OA MRI features. Only progression of meniscal extrusion was significantly diminished by the diet and exercise program.
  • References (40)
  • Citations (5)
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References40
Newest
Published on Mar 1, 2016in Osteoarthritis and Cartilage4.88
B.J.E. de Lange-Brokaar2
Estimated H-index: 2
(LEI: Leiden University),
J. Bijsterbosch15
Estimated H-index: 15
(LEI: Leiden University)
+ 7 AuthorsM. Kloppenburg50
Estimated H-index: 50
(LEI: Leiden University)
Objective: To investigate patterns of MRI abnormalities in the patellofemoral (PFJ) and tibiofemoral joint (TFJ) and their association with radiographic progression, using hypothesis free analyses. Design: 205 patients from the GARP study with symptomatic OA at multiple sites (mean age 60 years, 80% woman, median BMI 26 kg/m2), underwent knee MRI at baseline. Cartilage damage, osteophytes, cysts, bone marrow lesions (BMLs) and effusion/synovitis were scored according to a validated scoring metho...
Published on Feb 1, 2016in Seminars in Arthritis and Rheumatism5.07
J. Runhaar11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam),
Rita Deroisy24
Estimated H-index: 24
(University of Liège)
+ 9 AuthorsLucio Claudio Rovati29
Estimated H-index: 29
Abstract Background and objectives The PRevention of knee Osteoarthritis in Overweight Females (PROOF) study (ISRCTN 42823086) described a trend for a decrease in the incidence of knee osteoarthritis (OA) by a tailored diet and exercise program (DEP) or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage o...
Published on Feb 1, 2016in Nature Reviews Rheumatology18.55
Ewa M. Roos63
Estimated H-index: 63
,
N K Arden65
Estimated H-index: 65
(University of Oxford)
Osteoarthritis (OA) is a chronic condition that is associated with pain and disability. In this Review, Roos and Arden consider the strategies that are available for modification of risk factors contributing to the development of knee OA. Interventions for prevention and early care of knee OA could help to avoid joint-replacement surgery.
Published on Dec 1, 2015in Arthritis Research & Therapy4.15
Alex N. Bastick5
Estimated H-index: 5
,
J. Runhaar11
Estimated H-index: 11
+ 1 AuthorsSita M. A. Bierma-Zeinstra68
Estimated H-index: 68
Introduction We performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement.
Published on Sep 1, 2015in Clinical Orthopaedics and Related Research4.15
Alex N. Bastick5
Estimated H-index: 5
(EUR: Erasmus University Rotterdam),
Janneke N. Belo2
Estimated H-index: 2
(LUMC: Leiden University Medical Center)
+ 1 AuthorsSita M. A. Bierma-Zeinstra68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
Background A previous systematic review on prognostic factors for knee osteoarthritis (OA) progression showed associations for generalized OA and hyaluronic acid levels. Knee pain, radiographic severity, sex, quadriceps strength, knee injury, and regular sport activities were not associated. It has been a decade since the literature search of that review and many studies have been performed since then investigating prognostic factors for radiographic knee OA progression.
Published on Aug 1, 2015in The American Journal of Medicine4.76
J. Runhaar11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam),
Marienke van Middelkoop23
Estimated H-index: 23
(EUR: Erasmus University Rotterdam)
+ 6 AuthorsSita M. A. Bierma-Zeinstra68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
Abstract Background With accumulating knowledge on osteoarthritis development, the next step is to focus on possibilities for primary prevention. Methods In a 2 × 2 factorial design, the effects of a diet-and-exercise program and of oral glucosamine sulfate (double blind and placebo-controlled) on the incidence of knee osteoarthritis were evaluated in a high-risk group of 407 middle-aged women with a body mass index ≥ 27 kg/m 2 without clinical signs of knee osteoarthritis at baseline (ISRCTN 42...
Published on Jun 1, 2015in Journal of Biomechanics2.58
S.N. Edd3
Estimated H-index: 3
(Stanford University),
Nicholas J. Giori32
Estimated H-index: 32
(Stanford University),
Thomas P. Andriacchi76
Estimated H-index: 76
(Stanford University)
Meniscal damage and meniscectomy lead to subsequent osteoarthritis (OA) of the knee joint through multiple and diverse mechanisms, yet the interaction of these mechanisms remains unknown. Therefore, the aim of this review is to suggest the multi-scale, multi-faceted components involved between meniscal injury or meniscectomy and the initiation of OA. There is evidence of structural, mechanical, and biological changes after meniscal damage, all of which can be greatly affected by the presence of ...
Published on Oct 1, 2014in Osteoarthritis and Cartilage4.88
J. Runhaar11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam),
D. Schiphof11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam)
+ 3 AuthorsE.H. Oei9
Estimated H-index: 9
(EUR: Erasmus University Rotterdam)
Summary Objective Recently, the MRI Osteoarthritis Knee Score (MOAKS), a new semi-quantitative magnetic resonance imaging (MRI) scoring tool, was introduced by a panel of experienced researchers in osteoarthritis (OA). The MOAKS is primarily applicable to quantify OA status, since the interpretation of change in the MOAKS features was not described. In order to enable longitudinal evaluation, we propose definitions for progression and improvement of the main MOAKS features. Method Clear definiti...
Published on Jul 1, 2014in Arthritis & Rheumatism9.00
Leena Sharma54
Estimated H-index: 54
(NU: Northwestern University),
Joan S. Chmiel57
Estimated H-index: 57
(NU: Northwestern University)
+ 11 AuthorsC. Kent Kwoh40
Estimated H-index: 40
(UA: University of Arizona)
Objective Little is known about early knee osteoarthritis (OA). The significance of lesions on magnetic resonance imaging (MRI) in older persons without radiographic OA is unclear. Our objectives were to determine the extent of tissue pathology by MRI and evaluate its significance by testing the following hypotheses: cartilage damage, bone marrow lesions, and meniscal damage are associated with prevalent frequent knee symptoms and incident persistent symptoms; bone marrow lesions and meniscal da...
Published on Jul 1, 2014in Annals of the Rheumatic Diseases14.30
Marita Cross32
Estimated H-index: 32
(RNSH: Royal North Shore Hospital),
Emily R. Smith32
Estimated H-index: 32
(RNSH: Royal North Shore Hospital)
+ 15 AuthorsCatherine J. Hill47
Estimated H-index: 47
(University of Adelaide)
Objective To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions. Methods Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence, incidence and mortality risk. The prevalence and incidence of symptomatic, radiographic and self-reported hip or knee OA were included. Three levels of sever...
Cited By5
Newest
Published on Jun 22, 2018in British Journal of Sports Medicine11.64
Alessio Bricca2
Estimated H-index: 2
,
Carsten Bogh Juhl15
Estimated H-index: 15
(UCPH: University of Copenhagen)
+ 2 AuthorsEwa M. Roos63
Estimated H-index: 63
Objective To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs). Design We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data sources We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Control...
Published on Jun 9, 2018in British Journal of Sports Medicine11.64
Adam G Culvenor12
Estimated H-index: 12
,
Britt Elin Øiestad12
Estimated H-index: 12
(Metropolitan University)
+ 3 AuthorsKay M. Crossley56
Estimated H-index: 56
(La Trobe University)
Background Knee MRI is increasingly used to inform clinical management. Features associated with osteoarthritis are often present in asymptomatic uninjured knees; however, the estimated prevalence varies substantially between studies. We performed a systematic review with meta-analysis to provide summary estimates of the prevalence of MRI features of osteoarthritis in asymptomatic uninjured knees. Methods We searched six electronic databases for studies reporting MRI osteoarthritis feature preva...
Published on Apr 1, 2018in Seminars in Musculoskeletal Radiology1.17
Edwin H.G. Oei21
Estimated H-index: 21
(EUR: Erasmus University Rotterdam),
Marius C. Wick21
Estimated H-index: 21
(KI: Karolinska Institutet)
+ 2 AuthorsFalk Miese19
Estimated H-index: 19
Cartilage degeneration is one of the most common chronic age-related joint disorders leading to pain and reduced joint motion. The increasing prevalence of osteoarthritis requires accurate cartilage imaging, both clinically and in research. Detailed cartilage imaging is also necessary for traumatic cartilage lesions and for pre- and postoperative assessment of cartilage repair procedures. Although still widely used, conventional radiography bears significant limitations because it assesses carti...
Published on Aug 1, 2017in Osteoarthritis and Cartilage4.88
J.A. van der Voet1
Estimated H-index: 1
(EUR: Erasmus University Rotterdam),
J. Runhaar11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam)
+ 3 AuthorsSita M. A. Bierma-Zeinstra68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
Summary Objective To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological KOA at baseline. Methods 407 middle-aged overweight women (body mass index – BMI ≥ 27 kg/m 2 ) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS). The...
Published on Apr 1, 2016in Osteoarthritis and Cartilage4.88
Fan Zhang2
Estimated H-index: 2
(Lund University),
Sita M. A. Bierma-Zeinstra68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
+ 3 AuthorsJ. Runhaar11
Estimated H-index: 11
(EUR: Erasmus University Rotterdam)
Summary Objective To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). Design We used baseline data of the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1...
View next paperRisk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy.