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Planning for Research on Children During Public Health Emergencies.

Published on Feb 1, 2016in Pediatrics 5.40
· DOI :10.1542/peds.2015-3611
Laura J. Faherty3
Estimated H-index: 3
(Leonard Davis Institute of Health Economics),
Sonja A. Rasmussen62
Estimated H-index: 62
(CDC: Centers for Disease Control and Prevention),
Nicole Lurie52
Estimated H-index: 52
(Office of the Assistant Secretary for Preparedness and Response)
* Abbreviations: IRB — : institutional review board PHE — : public health emergency The recent Ebola epidemic exposed critical knowledge gaps about the disease and its impact on different populations, particularly children, which hindered the public health and medical response. For instance, unanswered questions remain about the natural history of Ebola virus disease in young children and its transmissibility in breast milk. Other emerging infectious diseases, such as Middle East Respiratory Syndrome (MERS), remind us that there will always be another pathogen lurking around the corner. Public health emergencies (PHEs) resulting from natural disasters are increasing in ferocity and frequency.1 How can we ensure that we address our current knowledge gaps to better prepare for future disasters? Awareness of the need to integrate scientific research into PHE response is growing,2 but the discussion of research involving children has been limited. Although several efforts have addressed the unique physical and socio-emotional needs of children in PHEs,3,4 pediatric research during PHEs has been lacking, resulting in significant knowledge gaps for children compared to adults. Conducting research, especially in children, without interfering with the PHE response is challenging. The present article discusses the importance of including children in PHE research and proposes components of a robust infrastructure that need to be in place to facilitate this research. Including children in PHE research presents special challenges, including issues with recruitment, informed consent, and enrollment.3,5 Institutional review boards (IRBs) have more stringent requirements for inclusion of children in research than for adults.6 A life course … Address correspondence to Laura J. Faherty, MD, MPH, Blockley Hall, 13th Floor, Room 1310, 423 Guardian Dr, Philadelphia, PA 19104. E-mail: lajohns{at}mail.med.upenn.edu
  • References (5)
  • Citations (2)
Published on May 1, 2015in Vaccine 3.27
James King1
Estimated H-index: 1
(Biomedical Advanced Research and Development Authority),
Yonghong Gao2
Estimated H-index: 2
(Biomedical Advanced Research and Development Authority)
+ 3 AuthorsEric M. Espeland1
Estimated H-index: 1
(Biomedical Advanced Research and Development Authority)
Abstract Background/objectives Anthrax vaccine adsorbed (AVA, BioThrax ® ) is recommended for post-exposure prophylaxis administration for the US population in response to large-scale Bacillus anthracis spore exposure. However, no information exists on AVA use in children and ethical barriers exist to performing pre-event pediatric AVA studies. A Presidential Ethics Commission proposed a potential pathway for such studies utilizing an age de-escalation process comparing safety and immunogenicity...
Michael T. Bartenfeld2
Estimated H-index: 2
Georgina Peacock12
Estimated H-index: 12
Stephanie Griese6
Estimated H-index: 6
Children represent nearly a quarter of the US population, but their unique needs in chemical, biological, radiological, and nuclear (CBRN) emergencies may not be well understood by public health and emergency management personnel or even clinicians. Children are different from adults physically, developmentally, and socially. These characteristics have implications for providing care in CBRN disasters, making resulting illness in children challenging to prevent, identify, and treat. This article...
Published on Nov 7, 2013in The New England Journal of Medicine 70.67
Jennifer Leaning21
Estimated H-index: 21
Debarati Guha-Sapir20
Estimated H-index: 20
Global disasters, both natural and man-made, affect health in many ways, as reviewed in this article in the Global Health series.
Published on Mar 28, 2013in The New England Journal of Medicine 70.67
Nicole Lurie52
Estimated H-index: 52
Teri A. Manolio101
Estimated H-index: 101
+ 2 AuthorsThomas R. Frieden46
Estimated H-index: 46
The authors review lessons learned from several recent public health emergencies and argue that we must conduct research during emergencies to improve our capacity to prevent illness and injury. They propose policies to facilitate timely research.
Published on Jan 1, 2008in Children, Youth and Environments
Lori Peek18
Estimated H-index: 18
This comprehensive overview of the literature on children and disasters argues that scholars and practitioners should more carefully consider the experiences of children themselves. As the frequency and intensity of disaster events increase around the globe, children are among those most at risk for the negative effects of disaster. Children are psychologically vulnerable and may develop post-traumatic stress disorder or related symptoms; are physically vulnerable to death, injury, illness, and ...