Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer
Volume: 26, Issue: 3, Pages: 824 - 828
Published: Feb 1, 2016
Abstract
The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key host dependency factors, is an especially appealing region for small molecule targeting. Using a field-based pharmacophore derived from an inhibitor known to interact with this region, coupled to biochemical and biological assessment, we have...
Paper Details
Title
Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer
Published Date
Feb 1, 2016
Volume
26
Issue
3
Pages
824 - 828
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