Match!

Infant Colic-What works: A Systematic Review of Interventions for Breast-fed Infants.

Published on May 1, 2016in Journal of Pediatric Gastroenterology and Nutrition3.02
· DOI :10.1097/MPG.0000000000001075
Tracy Harb2
Estimated H-index: 2
,
Misa Matsuyama3
Estimated H-index: 3
+ 1 AuthorsRebecca J. Hill15
Estimated H-index: 15
Cite
Abstract
Objectives: To determine the strength of evidence for commonly used interventions for colic in breast-fed and mixed-fed infants younger than 6 months. Methods: Searches of PubMed, CINAHL, Embase, AMED, and Web of Science databases were conducted from July 2014 to July 2015. Included studies were randomised controlled trials involving mothers and their colicky infants younger than 6 months; assessed colic against the Wessel or modified Wessel criteria; and included phytotherapies, prescription medicines, and maternal dietary interventions. Studies with <16 participants were excluded. Meta-analyses were conducted where data were sufficient to enable pooling. Quality was assessed against the Cochrane Risk Bias Assessment Tool. Results: A total of 17 articles met the inclusion criteria for this review. The 6 studies included for subgroup meta-analysis on probiotic treatment, notably Lactobacillus reuteri, demonstrated that probiotics appear an effective treatment, with an overall mean difference in crying time at day 21 of -55.8 min/day (95% CI -64.4 to -47.3, P=0.001). The 3 studies included for subgroup meta-analysis on preparations containing fennel suggest it to be effective, with an overall mean difference of -72.1 min/day (95% CI -126.4 to -17.7, P<0.001). Conclusions: Probiotics, in particular L reuteri, and preparations containing fennel oil appear effective for reducing colic, although there are limitations to these findings. The evidence for maternal dietary manipulation, lactase, sucrose, glucose, and simethicone is weak. Further well-designed clinical trials are required to strengthen the evidence for all of these interventions.
  • References (57)
  • Citations (38)
Cite
References57
Newest
Guo-Lin Mi1
Estimated H-index: 1
(SDU: Shandong University),
Lei Zhao1
Estimated H-index: 1
(Boston Children's Hospital)
+ 3 AuthorsJin-Ke Xu1
Estimated H-index: 1
(CDC: Centers for Disease Control and Prevention)
Infant colic, excessive crying of unknown cause, is a major burden to families and effects about 10–30 % of infants. Despite decades of research, the exact cause and treatment of infant colic has remained elusive. The use of Lactobacillus reuteri (DSM 17938) in infant colic is somewhat controversial and hence, we designed this study to evaluate its efficacy in infantile colic. We recruited predominantly or exclusively breastfed infants, aged less than 4 months in a placebo controlled observation...
Published on Jan 1, 2015in The Journal of Pediatrics3.74
Kim Chau3
Estimated H-index: 3
(U of T: University of Toronto),
Eddy Lau2
Estimated H-index: 2
(U of T: University of Toronto)
+ 4 AuthorsGideon Koren80
Estimated H-index: 80
Objective To investigate the effectiveness of Lactobacillus reuteri DSM 17938 for the treatment of infantile colic in breastfed Canadian infants, compared with placebo. Study design A randomized, double-blind, placebo-controlled trial was conducted involving 52 infants with colic, according to modified Wessel criteria, who were assigned at random to receive L reuteri DSM 17938 (10 8 colony-forming units) (n = 24) or placebo (n = 28) for 21 days. Daily crying and fussing times were recorded in a ...
Published on Dec 1, 2014in Italian Journal of Pediatrics1.73
Francesco Savino24
Estimated H-index: 24
(UNITO: University of Turin),
Simone Ceratto4
Estimated H-index: 4
(UNITO: University of Turin)
+ 1 AuthorsLuca Cordero di Montezemolo14
Estimated H-index: 14
(UNITO: University of Turin)
Infantile colic is a common disturbance occurring in the first three months of life. It is a benign condition and one of the main causes of pediatric consultation in the early part of life because of its great impact on family life. Some pediatricians are prone to undervalue this issue mainly because of the lack of evidence based medicine guidelines. Up to now, there is no consensus concerning management and treatment. Literature reports growing evidence about the effectiveness of dietary, pharm...
Published on Oct 1, 2014in European Journal of Pediatrics2.19
Magdalena Urbańska6
Estimated H-index: 6
(Medical University of Warsaw),
Hania Szajewska64
Estimated H-index: 64
(Medical University of Warsaw)
We aimed to systematically evaluate evidence on the effectiveness of Lactobacillus reuteri DSM 17938 (L. reuteri) for treating and preventing diseases in infants and children. MEDLINE and the Cochrane Library were searched in December 2013, with no language restrictions, for relevant randomized controlled trials (RCTs) and meta-analyses. The search was updated in April 2014. One systematic review and 14 RCTs met the inclusion criteria. The use of L. reuteri may be considered in the management of...
Published on Oct 1, 2014in Journal of Paediatrics and Child Health1.69
Hamid Reza Kianifar10
Estimated H-index: 10
(MUMS: Mashhad University of Medical Sciences),
Hamid Ahanchian11
Estimated H-index: 11
(Children's Medical Research Institute)
+ 5 AuthorsMohammad Ali Kiani12
Estimated H-index: 12
(MUMS: Mashhad University of Medical Sciences)
Aim: Infant colic is a frequent problem affecting up to 10–30% of infants in first 3 months of life. Results from previous trials have shown that manipulation of gut microbiota can lead to symptomatic improvements. In a randomised clinical trial, we aimed to determine efficacy of synbiotic in reducing average infant crying time at day 7 and day 30 after starting intervention. Methods: Fifty breastfed infants aged 15–120 days with infantile colic randomly assigned to receive either the synbiotic ...
Published on Apr 1, 2014in BMJ27.60
Sung1
Estimated H-index: 1
(University of Melbourne),
Harriet Hiscock34
Estimated H-index: 34
(University of Melbourne)
+ 7 AuthorsMelissa Wake58
Estimated H-index: 58
(University of Melbourne)
Objective To determine whether the probiotic Lactobacillus reuteri DSM 17938 reduces crying or fussing in a broad community based sample of breastfed infants and formula fed infants with colic aged less than 3 months. Design Double blind, placebo controlled randomised trial. Setting Community based sample (primary and secondary level care centres) in Melbourne, Australia. Participants 167 breastfed infants or formula fed infants aged less than 3 months meeting Wessel’s criteria for crying or fus...
Published on Dec 1, 2013in JAMA Pediatrics12.00
Valerie Sung8
Estimated H-index: 8
(University of Melbourne),
Sarsha Collett1
Estimated H-index: 1
(Monash University)
+ 3 AuthorsMelissa Wake58
Estimated H-index: 58
(University of Melbourne)
Importance Excessive infant crying is common, distressing, but without proven effective prevention or management options. Probiotics may be a promising solution. Objective To examine whether probiotics are effective in the prevention/management of crying (“colic”) in infants 3 months or younger. Data Sources A systematic search of MEDLINE, EMBASE, and the Cochrane Library, supplemented by the metaRegister of Controlled Trials. Study Selection Studies that randomized infants 3 months or younger t...
Published on Feb 1, 2013in The Journal of Pediatrics3.74
Hania Szajewska64
Estimated H-index: 64
(Medical University of Warsaw),
Ewa Gyrczuk1
Estimated H-index: 1
(Medical University of Warsaw),
Andrea Horvath19
Estimated H-index: 19
(Medical University of Warsaw)
Objective To determine whether administration of Lactobacillus reuteri ( L reuteri ) DSM 17938 is beneficial in breastfed infants with infantile colic. Study design Eighty infants aged 50%) breastfed were randomly assigned to receive L reuteri DSM 17938 (10 8 colony-forming units) (n = 40) or an identically appearing and tasting placebo (n = 40), both orally, in 5 drops, 1 time daily, for 21 days. The primary outcome measures were the treatment success, defined as the percentage of children achi...
Cited By38
Newest
Published on Jul 1, 2019in The Lancet Child & Adolescent Health
Celine Perceval (Vrije Universiteit Brussel), Hania Szajewska64
Estimated H-index: 64
(Medical University of Warsaw)
+ 2 AuthorsYvan Vandenplas52
Estimated H-index: 52
(Vrije Universiteit Brussel)
Summary The gastrointestinal microbiome is a hot topic in clinical research. Beneficial effects of selected probiotics in the prevention of gastrointestinal disorders are mainly restricted to acute gastroenteritis, antibiotic-associated diarrhoea, infantile colic, and necrotising enterocolitis. However, no broad consensus exists to recommend the use of probiotics in the prevention of these conditions, mainly because of the different design of the studies done so far, resulting in little evidence...
Published on Jun 1, 2019in Complementary Therapies in Medicine1.98
Christa Raak7
Estimated H-index: 7
(Witten/Herdecke University),
Peter Krueger (Witten/Herdecke University)+ 6 AuthorsOstermann Thomas26
Estimated H-index: 26
(Witten/Herdecke University)
Abstract Objectives Infantile colic is a common benign disease occurring in early infancy that may have a great impact on family life. In the present study, the effectiveness and safety of the complex homeopathic medicine Enterokind was compared with Simethicone for treating infantile colic. Design and setting Current data were drawn from a prospective, multicenter, randomized, open-label, controlled clinical trial that was conducted in 2009 in 3 Russian outpatient clinics. Children received eit...
Published on Mar 1, 2019in Canadian Family Physician2.19
Monica Kidd2
Estimated H-index: 2
,
Melanie Hnatiuk + 2 AuthorsMaria Palacios Mackay1
Estimated H-index: 1
(U of C: University of Calgary)
Abstract Objective To investigate new mothers’ perceptions about the role of maternal diet in infant fuss-cry behaviour, and to explore patterns of food restriction in breastfeeding women. Design Qualitative study. Setting Calgary, Alta. Participants Twenty-one mothers of healthy singleton infants aged 6 months and younger. Methods Focus groups and one-on-one interviews with a semistructured interview guide, followed by content analysis. Main findings Most respondents believed that infant cry-fu...
Published on Jan 2, 2019in Journal of Maternal-fetal & Neonatal Medicine1.57
Janki Deshmukh1
Estimated H-index: 1
(PMH: Princess Margaret Hospital for Children),
Mangesh Deshmukh4
Estimated H-index: 4
(St John of God Subiaco Hospital),
Sanjay Patole31
Estimated H-index: 31
(King Edward Memorial Hospital)
AbstractBackground: Neonatal jaundice requiring phototherapy is associated with significant socioeconomic burden including hospital readmission, prolonged hospital stay, and separation of the baby from mother.Objectives: To assess the efficacy and safety of probiotics in reducing the need for phototherapy and its duration in neonatal hyperbilirubinemia.Methods: A systematic review of randomized controlled trials (RCTs) of probiotic supplementation for prevention or treatment of jaundice in neona...
Yvan Vandenplas52
Estimated H-index: 52
(Vrije Universiteit Brussel),
Bruno Hauser25
Estimated H-index: 25
(Vrije Universiteit Brussel),
Silvia Salvatore20
Estimated H-index: 20
(University of Insubria)
Published on Dec 1, 2018in The Journal of Pediatrics3.74
J. Marc Rhoads25
Estimated H-index: 25
(University of Texas Health Science Center at Houston),
J Collinsjr122
Estimated H-index: 122
(BCM: Baylor College of Medicine)
+ 8 AuthorsMelissa R Van Arsdall9
Estimated H-index: 9
(University of Texas Health Science Center at Houston)
Objective To dissect potential confounding effects of breast milk and formula feeding on crying + fussing, fecal calprotectin, and gut microbiota in babies with colic. We hypothesized that infant colic is associated with gut inflammation linked to intestinal dysbiosis. Study design A nested case-control design of 3 of our studies was used to analyze clinical and laboratory data at presentation, comparing babies with colic with controls. All investigators other than the biostatistician were blind...
Published on Dec 1, 2018in Gastroenterology Clinics of North America3.37
Tu Mai (University of Texas Health Science Center at Houston), Nicole Y. Fatheree10
Estimated H-index: 10
(University of Texas Health Science Center at Houston)
+ 2 AuthorsJon Marc Rhoads7
Estimated H-index: 7
Published on Oct 18, 2018in Nutrients4.17
Yuying Liu12
Estimated H-index: 12
,
Jane J. Alookaran1
Estimated H-index: 1
(University of Texas Health Science Center at Houston),
J. Marc Rhoads1
Estimated H-index: 1
Probiotics have been used to ameliorate gastrointestinal symptoms since ancient times. Over the past 40 years, probiotics have been shown to impact the immune system, both in vivo and in vitro. This interaction is linked to gut microbes, their polysaccharide antigens, and key metabolites produced by these bacteria. At least four metabolic pathways have been implicated in mechanistic studies of probiotics, based on mechanistic studies in animal models. Microbial–immune system crosstalk has been l...
Published on Oct 1, 2018in The Journal of Clinical Pharmacology2.92
Yuying Liu12
Estimated H-index: 12
(University of Texas Health Science Center at Houston),
Dat Q. Tran6
Estimated H-index: 6
(University of Texas Health Science Center at Houston),
J. Marc Rhoads25
Estimated H-index: 25
(University of Texas Health Science Center at Houston)
Published on Sep 7, 2018in F1000Research
Siel Daelemans1
Estimated H-index: 1
(Vrije Universiteit Brussel),
Linde Peeters1
Estimated H-index: 1
(Vrije Universiteit Brussel)
+ 1 AuthorsYvan Vandenplas52
Estimated H-index: 52
(Vrije Universiteit Brussel)
A newborn brings joy to the family. Crying belongs to the spectrum of normal behaviour of young infants. However, although it occurs in about 20% of all infants, unsoothable and persistent crying in young infants distresses the family, although it is usually benign. The aetiology of infantile colic remains unknown, although an unbalanced gastro-intestinal microbiome, increased intestinal permeability, and chronic inflammation are involved, as well as behavioural factors, including over- and unde...
View next paperChildhood functional gastrointestinal disorders: neonate/toddler