Trans-fatty acids and mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study

Published on Apr 1, 2016in European Heart Journal23.24
· DOI :10.1093/eurheartj/ehv446
Marcus E. Kleber47
Estimated H-index: 47
(Heidelberg University),
Graciela Delgado21
Estimated H-index: 21
(Heidelberg University)
+ 2 AuthorsClemens von Schacky26
Estimated H-index: 26
(LMU: Ludwig Maximilian University of Munich)
Aims Trans -fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate the association of TFA with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Methods and results The fatty acid composition of erythrocyte membranes was analysed using the HS-Omega-3 Index® methodology in 3259 participants of the LURIC study at baseline. During a median of 10.0 years of follow-up, a total of 975 (29.9%) study participants died, 614 (18.8%) from cardiovascular causes including 254 (7.8%) sudden cardiac deaths (SCDs). Association of TFA with clinical outcome was investigated with Cox proportional hazards regression. Total TFAs were inversely associated with mortality due to cardiovascular causes or SCD. This was mainly driven by the naturally occurring TFA C16:1n-7t ( trans -palmitoleic acid). The reduced risk of SCD associated with C16:1n-7t persisted after multivariate adjustment with a hazard ratio of 0.63 (0.46–0.86) for the third tertile compared with the first tertile. There was no association of any TFA subgroup with an increased risk of adverse outcomes. Conclusions In contrast to previous findings, the low concentrations of total TFAs found in LURIC were inversely associated with adverse cardiac outcomes. While the naturally occurring TFA C16:1n-7t was associated with reduced risk, no increased risk was found for industrially produced TFAs.
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  • Citations (46)
Published on Aug 28, 2014in Preventing Chronic Disease2.04
Jenifer Clapp3
Estimated H-index: 3
Christine J. Curtis8
Estimated H-index: 8
+ 1 AuthorsGail P. Goldstein1
Estimated H-index: 1
Although there is evidence that consumption of trans fat has declined in the United States, limited documentation exists on current levels of industrial trans fat in foods. We estimated the prevalence of partially hydrogenated oils in 4,340 top-selling US packaged foods. Nine percent of products in the sample contained partially hydrogenated oils; 84% of these products listed “0 grams” of trans fat per serving, potentially leading consumers to underestimate their trans fat consumption. Governmen...
Published on Aug 15, 2014in Journal of the American Heart Association4.66
Qianyi Wang4
Estimated H-index: 4
(Harvard University),
Fumiaki Imamura27
Estimated H-index: 27
(University of Cambridge)
+ 6 AuthorsDariush Mozaffarian113
Estimated H-index: 113
Background While self-reported trans– fatty acid (TFA) consumption is linked to coronary heart disease (CHD), relationships between objective biomarkers of TFA subtypes ( t- 16:1n9, total t- 18:1, and cis / trans- ( c / t- ), t / c- and t / t- 18:2) and cardiovascular disease (CVD) or total mortality are not well established. Methods and Results We evaluated 2742 adults in the Cardiovascular Health Study, aged 74±5 years and free of prevalent CVD, with plasma phospholipid TFA measures in 1992. I...
Published on May 1, 2014in BMJ Open2.38
Stefan Stender46
Estimated H-index: 46
(Copenhagen University Hospital),
A. Astrup92
Estimated H-index: 92
(UCPH: University of Copenhagen),
Jørn Dyerberg4
Estimated H-index: 4
(Copenhagen University Hospital)
Objective: To minimise the intake of industrial artificial trans fat (I-TF), nearly all European countries rely on food producers to voluntarily reduce the I-TF content in food. The objective of this study was to investigate the effect of this strategy on I-TF content in prepackaged biscuits/cakes/wafers in 2012–2013 in 20 European countries. Design: The I-TF content was assessed in a market basket investigation. Three large supermarkets were visited in each capital, and in some countries, three...
Published on Mar 18, 2014in Annals of Internal Medicine19.32
Rajiv Chowdhury47
Estimated H-index: 47
Samantha Warnakula9
Estimated H-index: 9
+ 11 AuthorsSimon G. Thompson95
Estimated H-index: 95
Primary Funding Source: British Heart Foundation, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, and Gates Cambridge.
Published on Mar 1, 2014in Clinical Therapeutics2.94
Paul Nestel1
Estimated H-index: 1
Abstract Objective The goal of this article was to review the causal link between trans fatty acids (TFA) produced from partially hydrogenated vegetable oil (PHVO) and cardiovascular disease (CVD) risk and its likely mechanisms. The potential risk of TFA from ruminant dairy and meats, which are currently the major sources of dietary TFA, is also discussed. Methods Evidence was derived from observational studies of large cohorts followed up prospectively; from randomized controlled trials of clin...
Published on Mar 1, 2014in The American Journal of Clinical Nutrition6.57
Anke Jaudszus8
Estimated H-index: 8
(FSU: University of Jena),
Ronny Kramer8
Estimated H-index: 8
(FSU: University of Jena)
+ 3 AuthorsKatrin Kuhnt12
Estimated H-index: 12
(FSU: University of Jena)
Background: trans Palmitoleic acid (t-16:1n–7, or 16:1t 9i n thed nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease. Objective: Although 16:1t9 has been assumed to derive from dietary sources, we examined the hypothesis that 16:1t9 might also be endogenously produced from its metabolic precursor vaccenic acid (t-18:1n–7 or 18:1t11...
Published on Oct 9, 2013in PLOS ONE2.78
Edward Archer17
Estimated H-index: 17
(USC: University of South Carolina),
Gregory A. Hand28
Estimated H-index: 28
(USC: University of South Carolina),
Steven N. Blair140
Estimated H-index: 140
(USC: University of South Carolina)
Importance Methodological limitations compromise the validity of U.S. nutritional surveillance data and the empirical foundation for formulating dietary guidelines and public health policies. Objectives Evaluate the validity of the National Health and Nutrition Examination Survey (NHANES) caloric intake data throughout its history, and examine trends in the validity of caloric intake estimates as the NHANES dietary measurement protocols evolved. Design Validity of data from 28,993 men and 34,369...
Published on Sep 1, 2013in Atherosclerosis4.25
Kuo-Liong Chien40
Estimated H-index: 40
(NTU: National Taiwan University),
Hung-Ju Lin49
Estimated H-index: 49
(NTU: National Taiwan University)
+ 4 AuthorsYuan-Teh Lee45
Estimated H-index: 45
(NTU: National Taiwan University)
Abstract Background The issue of whether saturated fats and trans fats are superior predictors of all-cause death and cardiovascular disease than n-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), remains a matter of contention. Furthermore, few studies have examined the relationship between fatty acids and the outcomes of cardiovascular disease (CVD) in Asian populations. The aim of this study was to compare the effectiveness of various plasma f...
Published on May 1, 2013in British Journal of Nutrition3.32
Xiao-Ru Liu5
Estimated H-index: 5
(NCU: Nanchang University),
Ze-Yuan Deng6
Estimated H-index: 6
(NCU: Nanchang University)
+ 7 AuthorsWei-Feng Li1
Estimated H-index: 1
(NCU: Nanchang University)
Industry-generated trans- fatty acids (TFA) are detrimental to risk of CHD, but ruminant-originated TFA have been reported as neutral or equivocal. Therefore, the total TFA amount should not be the only factor considered when measuring the effects of TFA. In the present study, we addressed whether a version of the TFA index that unifies the effects of different TFA isomers into one equation could be used to reflect CHD risk probability (RP). The present cross-sectional study involved 2713 indivi...
Published on Apr 1, 2013in The American Journal of Clinical Nutrition6.57
Oluwabunmi Tokede8
Estimated H-index: 8
(Harvard University),
Andrew B. Petrone11
Estimated H-index: 11
(Harvard University)
+ 5 AuthorsLuc Djoussé57
Estimated H-index: 57
(Harvard University)
Background: Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF). Objective: Our goal was to assess associations of plasma and dietary TFAs with HF and CAD. Design: We used a prospective, nested case-control design to select 788 incident HF cases and 788 matched controls from the Physicians’ Health Study for biomarker analyses and a prospective cohort for the dietary anal...
Cited By46
Published on Jul 1, 2019in Prostaglandins Leukotrienes and Essential Fatty Acids2.86
William S. Harris74
Estimated H-index: 74
(USD: University of South Dakota),
K.H. Jackson + 3 AuthorsL. Cornish
Abstract Background The Omega-3 Index (O3I; erythrocyte EPA+DHA as a percent of total fatty acids) is inversely related to risk for cardiovascular disease (CVD). The cardioprotective target O3I is 8%-12%. O3I levels in American regions with high CVD risk are poorly characterized. Purpose To determine the O3I in individuals participating in a Seafood Nutrition Partnership (SNP) survey in seven US cities in the CVD “belt.” Methods Fingerstick blood samples were analyzed for the O3I. Results The SN...
Published on Jul 1, 2019in Trends in Cardiovascular Medicine4.46
Bhavi Shah (University of Oklahoma Health Sciences Center), Udho Thadani29
Estimated H-index: 29
(University of Oklahoma Health Sciences Center)
Abstract Consumption of industrially produced trans fatty acids (IP-TFAs) increases LDL cholesterol, either decreases or has no effect on HDL cholesterol, and increases markers of inflammation. Observational studies have shown that consumption of TFA produced by partial hydrogenation of vegetable oils (PHOs) is associated with increased mortality and incidence of MI and stroke rates. Regulatory initiatives to restrict PHOs to less than 2 g per day from food sources, along with concurrent initiat...
Published on Jul 1, 2019in Journal of Clinical Lipidology3.58
William S. Harris74
Estimated H-index: 74
(USD: University of South Dakota),
Kristina Harris Jackson4
Estimated H-index: 4
Abstract Background The REDUCE-IT study demonstrated that 4 g/day of eicosapentaenoic acid (EPA) ethyl esters (icosapent ethyl, IPE) reduced risk for major cardiovascular events by 25% in statin-treated patients with residual hypertriglyceridemia. How this treatment affected red blood cell (RBC) EPA and docosahexaenoic acid (DHA) levels (i.e., the omega-3 index, O3I) was not reported, but effects on plasma EPA concentrations were. Objective To estimate baseline and final O3I levels in REDUCE-IT ...
Published on May 1, 2019in Atherosclerosis4.25
Shinji Koba25
Estimated H-index: 25
(Showa University),
Tetsuya Takao2
Estimated H-index: 2
(Showa Women's University)
+ 8 AuthorsWilliam S. Harris74
Estimated H-index: 74
(USD: University of South Dakota)
Abstract Background and aims It remains unclear how trans fatty acid (TFA) at low-level intake affect lipid levels and the development of acute coronary syndrome (ACS). The study aimed to investigate how plasma TFA composition differs between male patients with ACS and healthy men. Methods Plasma fatty acid (FA) composition (as determined by gas chromatography) was analyzed in ACS patients on hospital admission and compared to that of age-adjusted healthy men. Results Total FA and TFA levels wer...
Published on Feb 1, 2019in Food and Chemical Toxicology3.77
Farkas Sarnyai (Semmelweis University), Mária Berinkeiné Donkó (BME: Budapest University of Technology and Economics)+ 11 AuthorsPéter Lőw6
Estimated H-index: 6
(ELTE: Eötvös Loránd University)
Abstract High fatty acid (FA) levels are deleterious to pancreatic β-cells, largely due to the accumulation of biosynthetic lipid intermediates, such as ceramides and diglycerides, which induce ER stress and apoptosis. Toxicity of palmitate (16:0) and oleate (18:1 cis-Δ 9 ) has been widely investigated, while very little data is available on the cell damages caused by elaidate (18:1 trans-Δ 9 ) and vaccenate (18:1 trans-Δ 11 ), although the potential health effects of these dietary trans fatty a...
Published on Feb 1, 2019in Nutrition Metabolism and Cardiovascular Diseases3.34
Daniel Medenwald5
Estimated H-index: 5
(MLU: Martin Luther University of Halle-Wittenberg),
Alexander Kluttig20
Estimated H-index: 20
(MLU: Martin Luther University of Halle-Wittenberg)
+ 1 AuthorsJ. Schumann
Abstract Background and Aims Diet is known to play a decisive role in the development of coronary heart disease (CHD). One factor believed to decrease lifetime risk of CHD is the consumption of omega-3 fatty acids. Yet, conclusive evidence regarding the potential cardioprotective effects of fatty acids is far from being reached. The present study aimed to provide further evidence on the association of serum fatty acid profiles with CHD risk. Methods and Results The CARdio-vascular Disease, Livin...
Published on Jan 1, 2019in Diabetologe0.19
Stefan Lorkowski34
Estimated H-index: 34
(FSU: University of Jena),
Christine Dawczynski10
Estimated H-index: 10
(FSU: University of Jena)
Die Verbesserung der Nahrungsfettqualitat ist bei Diabetes-Patienten mit einer Hypercholesterolamie ein wesentlicher Baustein der Ernahrungsumstellung zum Erhalt der kardiovaskularen Gesundheit und zur Reduktion des kardiovaskularen Risikos. Ebenso wie bei einer isolierten Hypercholesterolamie sollten bei der diabetischen Dyslipoproteinamie die Zufuhr industriell erzeugter Transfettsauren minimiert sowie der Verzehr gesattigter Fettsauren zugunsten einer erhohten Aufnahme von einfach und mehrfac...
Published on Nov 1, 2018in Trends in Food Science and Technology8.52
Pilar Gómez-Cortés15
Estimated H-index: 15
(CSIC: Spanish National Research Council),
Manuela Juárez34
Estimated H-index: 34
(CSIC: Spanish National Research Council),
Miguel Ángel de la Fuente Layos30
Estimated H-index: 30
(CSIC: Spanish National Research Council)
Abstract Background Milk fat intake is often associated with a high risk of suffering from cardiovascular disease (CVD) due to its high saturated fat content. However, not all saturated fatty acids (SFA) are equal and they present structural differences that promote distinct effects on the biological processes. In addition, there is a growing scientific consensus pointing to dairy fat as a natural source of bioactive components. Scope and approach The present review provides the most recent know...
Published on Aug 1, 2018in Public Health Nutrition2.53
Magdalena Makarewicz-Wujec5
Estimated H-index: 5
(Medical University of Warsaw),
Anna Maria Dworakowska1
Estimated H-index: 1
(Medical University of Warsaw),
Małgorzata Kozłowska-Wojciechowska8
Estimated H-index: 8
(Medical University of Warsaw)
Objective To present and discuss results of the most recent studies pertaining to the effects of consumption of different types of fatty acids on the risk of CVD. The aim was also an attempt to answer the question of whether a revision of the current recommendations is necessary. Design A review of prospective cohort studies, systematic reviews and meta-analyses published in 2014–2017 on the effects of SFA and trans -fatty acid (TFA) intakes as well as various models of their replacement in the ...