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Trans-fatty acids and mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study

Published on Apr 1, 2016in European Heart Journal23.24
· DOI :10.1093/eurheartj/ehv446
Marcus E. Kleber47
Estimated H-index: 47
(Heidelberg University),
Graciela Delgado21
Estimated H-index: 21
(Heidelberg University)
+ 2 AuthorsClemens von Schacky26
Estimated H-index: 26
(LMU: Ludwig Maximilian University of Munich)
Abstract
Aims Trans -fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate the association of TFA with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Methods and results The fatty acid composition of erythrocyte membranes was analysed using the HS-Omega-3 Index® methodology in 3259 participants of the LURIC study at baseline. During a median of 10.0 years of follow-up, a total of 975 (29.9%) study participants died, 614 (18.8%) from cardiovascular causes including 254 (7.8%) sudden cardiac deaths (SCDs). Association of TFA with clinical outcome was investigated with Cox proportional hazards regression. Total TFAs were inversely associated with mortality due to cardiovascular causes or SCD. This was mainly driven by the naturally occurring TFA C16:1n-7t ( trans -palmitoleic acid). The reduced risk of SCD associated with C16:1n-7t persisted after multivariate adjustment with a hazard ratio of 0.63 (0.46–0.86) for the third tertile compared with the first tertile. There was no association of any TFA subgroup with an increased risk of adverse outcomes. Conclusions In contrast to previous findings, the low concentrations of total TFAs found in LURIC were inversely associated with adverse cardiac outcomes. While the naturally occurring TFA C16:1n-7t was associated with reduced risk, no increased risk was found for industrially produced TFAs.
  • References (41)
  • Citations (46)
References41
Newest
#1Stefan Stender (Copenhagen University Hospital)H-Index: 46
#2A. Astrup (UCPH: University of Copenhagen)H-Index: 92
Last.Jørn Dyerberg (Copenhagen University Hospital)H-Index: 4
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#1Anke Jaudszus (FSU: University of Jena)H-Index: 8
#2Ronny Kramer (FSU: University of Jena)H-Index: 8
Last.Katrin Kuhnt (FSU: University of Jena)H-Index: 12
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#1Edward Archer (USC: University of South Carolina)H-Index: 17
#2Gregory A. Hand (USC: University of South Carolina)H-Index: 28
Last.Steven N. Blair (USC: University of South Carolina)H-Index: 140
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#1Kuo-Liong Chien (NTU: National Taiwan University)H-Index: 40
#2Hung-Ju Lin (NTU: National Taiwan University)H-Index: 49
Last.Yuan-Teh Lee (NTU: National Taiwan University)H-Index: 45
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#1Xiao-Ru Liu (NCU: Nanchang University)H-Index: 5
#2Ze-Yuan Deng (NCU: Nanchang University)H-Index: 6
Last.Wei-Feng Li (NCU: Nanchang University)H-Index: 1
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#1Oluwabunmi Tokede (Harvard University)H-Index: 8
#2Andrew B. Petrone (Harvard University)H-Index: 11
Last.Luc Djoussé (Harvard University)H-Index: 58
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Cited By46
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#1Bhavi Shah (University of Oklahoma Health Sciences Center)
#2Udho Thadani (University of Oklahoma Health Sciences Center)H-Index: 29
#1Farkas Sarnyai (Semmelweis University)
#2Mária Berinkeiné Donkó (BME: Budapest University of Technology and Economics)
Last.Miklós Csala (Semmelweis University)H-Index: 27
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#1Daniel Medenwald (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 5
#2Alexander Kluttig (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 20
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